SARS-CoV-2-IN-11

Modify Date: 2024-01-05 18:13:46

SARS-CoV-2-IN-11 Structure
SARS-CoV-2-IN-11 structure
Common Name SARS-CoV-2-IN-11
CAS Number 2722635-28-9 Molecular Weight 625.66
Density N/A Boiling Point N/A
Molecular Formula C27H38F2N3NaO8S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of SARS-CoV-2-IN-11


SARS-CoV-2-IN-11 is a potent and nontoxic inhibitor of SARS-CoV-2 3CL protease (3CLpro) with an IC50 and EC50 of 0.17 and 1.45 nM, respectively. SARS-CoV-2 3C-like protease (3CLpro), an enzyme essential for viral replication, is an attractive target for therapeutic intervention. SARS-CoV-2-IN-11 may lead to the emergence of effective SARS-CoV-2-specific antivirals[1].

 Names

Name SARS-CoV-2-IN-11

 SARS-CoV-2-IN-11 Biological Activity

Description SARS-CoV-2-IN-11 is a potent and nontoxic inhibitor of SARS-CoV-2 3CL protease (3CLpro) with an IC50 and EC50 of 0.17 and 1.45 nM, respectively. SARS-CoV-2 3C-like protease (3CLpro), an enzyme essential for viral replication, is an attractive target for therapeutic intervention. SARS-CoV-2-IN-11 may lead to the emergence of effective SARS-CoV-2-specific antivirals[1].
Related Catalog
Target

SARS-CoV-2 3C-like proteas[1]

References

[1]. Dampalla CS, et al. Structure-Guided Design of Potent Inhibitors of SARS-CoV-2 3CL Protease: Structural, Biochemical, and Cell-Based Studies. J Med Chem. 2021;64(24):17846-17865.

 Chemical & Physical Properties

Molecular Formula C27H38F2N3NaO8S
Molecular Weight 625.66