755753-89-0

755753-89-0 structure

Name: Org 48762-0
Chemical Name: Org 48762-0
CAS Number: 755753-89-0
Molecular Formula: C₂₄H₁₆F₂N₄
Molecular Weight: 398.41
Catalog: Signaling Pathways MAPK/ERK Pathway p38 MAPK
Create Date: 2022-03-28 12:35:05
Modify Date: 2024-01-12 10:35:28
Org 48762-0 is a potent, orally active and selective p38 inhibitor with EC50 of 0.1 μM. Org 48762-0 reduces LPS-induced TNFα release and prevents bone damage in collagen-induced arthritis in mice[1].

Name	Org 48762-0
Synonyms	2H-Pyrazolo[3,4-b]pyridine, 4,6-bis(4-fluorophenyl)-2-methyl-5-(4-pyridinyl)- 4,6-Bis(4-fluorophenyl)-2-methyl-5-(4-pyridinyl)-2H-pyrazolo[3,4-b]pyridine MFCD30536377

Description	Org 48762-0 is a potent, orally active and selective p38 inhibitor with EC50 of 0.1 μM. Org 48762-0 reduces LPS-induced TNFα release and prevents bone damage in collagen-induced arthritis in mice[1].
Related Catalog	Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK Research Areas >> Inflammation/Immunology
References	[1]. K Mihara, et al. A potent and selective p38 inhibitor protects against bone damage in murine collagen-induced arthritis: a comparison with neutralization of mouse TNFalpha. Br J Pharmacol. 2008 May;154(1):153-64.