Org 48762-0

Modify Date: 2024-01-12 10:35:28

Org 48762-0 Structure
Org 48762-0 structure
Common Name Org 48762-0
CAS Number 755753-89-0 Molecular Weight 398.41
Density 1.3±0.1 g/cm3 Boiling Point 520.1±50.0 °C at 760 mmHg
Molecular Formula C24H16F2N4 Melting Point N/A
MSDS N/A Flash Point 268.3±30.1 °C

 Use of Org 48762-0


Org 48762-0 is a potent, orally active and selective p38 inhibitor with EC50 of 0.1 μM. Org 48762-0 reduces LPS-induced TNFα release and prevents bone damage in collagen-induced arthritis in mice[1].

 Names

Name Org 48762-0
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 Org 48762-0 Biological Activity

Description Org 48762-0 is a potent, orally active and selective p38 inhibitor with EC50 of 0.1 μM. Org 48762-0 reduces LPS-induced TNFα release and prevents bone damage in collagen-induced arthritis in mice[1].
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References

[1]. K Mihara, et al. A potent and selective p38 inhibitor protects against bone damage in murine collagen-induced arthritis: a comparison with neutralization of mouse TNFalpha. Br J Pharmacol. 2008 May;154(1):153-64.   

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 520.1±50.0 °C at 760 mmHg
Molecular Formula C24H16F2N4
Molecular Weight 398.41
Flash Point 268.3±30.1 °C
Exact Mass 398.134308
LogP 3.62
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.661

 Synonyms

2H-Pyrazolo[3,4-b]pyridine, 4,6-bis(4-fluorophenyl)-2-methyl-5-(4-pyridinyl)-
4,6-Bis(4-fluorophenyl)-2-methyl-5-(4-pyridinyl)-2H-pyrazolo[3,4-b]pyridine
MFCD30536377
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