1429012-38-3

1429012-38-3 structure

Name: hGGPPS-IN-1
Chemical Name: hGGPPS-IN-1
CAS Number: 1429012-38-3
Molecular Formula: C₁₃H₁₃N₃O₆P₂S
Molecular Weight: 401.27
Create Date: 2022-05-17 11:50:34
Modify Date: 2024-01-08 10:57:14
hGGPPS-IN-1 (Compound 18b) is a potent inhibitor of the human geranylgeranyl pyrophosphate synthase (hGGPPS). hGGPPS-IN-1 is an analogue of C-2-substituted thienopyrimidine-based bisphosphonates (C2-ThP-BPs). hGGPPS-IN-1 induces target-selective apoptosis of multiple myeloma (MM) cells and exhibits antimyeloma activity in vivo[1].

Name	hGGPPS-IN-1

Description	hGGPPS-IN-1 (Compound 18b) is a potent inhibitor of the human geranylgeranyl pyrophosphate synthase (hGGPPS). hGGPPS-IN-1 is an analogue of C-2-substituted thienopyrimidine-based bisphosphonates (C2-ThP-BPs). hGGPPS-IN-1 induces target-selective apoptosis of multiple myeloma (MM) cells and exhibits antimyeloma activity in vivo[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
References	[1]. Lee HF, et al. Synthesis and Evaluation of Structurally Diverse C-2-Substituted Thienopyrimidine-Based Inhibitors of the Human Geranylgeranyl Pyrophosphate Synthase. J Med Chem. 2022;65(3):2471-2496.

Molecular Formula	C₁₃H₁₃N₃O₆P₂S
Molecular Weight	401.27