2695505-82-7
2695505-82-7 structure
- Name: RAF-IN-1
- Chemical Name: RAF-IN-1
- CAS Number: 2695505-82-7
- Molecular Formula: C26H22F3N3O4
- Molecular Weight: 497.47
- Create Date: 2022-07-09 15:57:04
- Modify Date: 2024-01-08 12:25:57
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RAF-IN-1 is a potent b/cRAF inhibitor with an IC50s of 3.8 nM, 36 nM, 29.4 nM for cRAF, bRAFwt, and bRAFV600E. RAF-IN-1 shows cell growth inhibition with GI50s of 3.4 and 2.9 nM for H358 and A375 cell line bearing bRAFV600E mutation, respectively[1].
| Name | RAF-IN-1 |
|---|
| Description | RAF-IN-1 is a potent b/cRAF inhibitor with an IC50s of 3.8 nM, 36 nM, 29.4 nM for cRAF, bRAFwt, and bRAFV600E. RAF-IN-1 shows cell growth inhibition with GI50s of 3.4 and 2.9 nM for H358 and A375 cell line bearing bRAFV600E mutation, respectively[1]. |
|---|---|
| Related Catalog | |
| Target |
BRafV600E:29.4 nM (IC50) BRAFWT:36 nM (IC50) c-Raf:3.8 nM (IC50) |
| References |
| Molecular Formula | C26H22F3N3O4 |
|---|---|
| Molecular Weight | 497.47 |