Shanghai Nianxing Industrial Co., Ltd
China
Product Name: ZK824190 hydrochloride
Price: Check
Purity: 99.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: ZK824190 hydrochloride
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

2629177-12-2

2629177-12-2 structure

2629177-12-2 structure

Name: ZK824190 hydrochloride
Chemical Name: ZK824190 hydrochloride
CAS Number: 2629177-12-2
Molecular Formula: C₂₂H₂₁ClF₂N₂O₄
Molecular Weight: 450.86
Create Date: 2022-05-06 17:25:24
Modify Date: 2025-08-26 18:03:47
ZK824190 hydrochloride is an orally available and selective urokinase plasminogen activator (uPA) inhibitor as a potential treatment for multiple sclerosis. IC50s of 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively[1].

Name	ZK824190 hydrochloride

Description	ZK824190 hydrochloride is an orally available and selective urokinase plasminogen activator (uPA) inhibitor as a potential treatment for multiple sclerosis. IC50s of 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> PAI-1 Signaling Pathways >> Metabolic Enzyme/Protease >> Ser/Thr Protease Research Areas >> Inflammation/Immunology
In Vivo	ZK824190 (2 mg/kg; PO; Rats with EAE model) exhibits a relatively high oral availability and a moderate half time (T1/2=2.8 h)[1].
References	[1]. Islam I, et al. Discovery of selective urokinase plasminogen activator (uPA) inhibitors as a potential treatment for multiple sclerosis. Bioorg Med Chem Lett. 2018 Nov 1;28(20):3372-3375.

Molecular Formula	C₂₂H₂₁ClF₂N₂O₄
Molecular Weight	450.86

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