2254004-96-9

2254004-96-9 structure

Name: DDO-7263
Chemical Name: DDO-7263
CAS Number: 2254004-96-9
Molecular Formula: C₁₄H₉F₂N₃O
Molecular Weight: 273.24
Catalog: Signaling Pathways NF-κB Keap1-Nrf2
Create Date: 2022-05-29 00:06:50
Modify Date: 2024-01-09 00:49:53
DDO-7263, a 1,2,4-Oxadiazole derivative, is a potent Nrf2 activator. DDO-7263 upregulates Nrf2 through binding to Rpn6 to block the assembly of 26S proteasome and the subsequent degradation of ubiquitinated Nrf2. DDO-7263 activates the Nrf2-ARE signaling pathway and exerts anti-inflammatory activity[1].

Name	DDO-7263

Description	DDO-7263, a 1,2,4-Oxadiazole derivative, is a potent Nrf2 activator. DDO-7263 upregulates Nrf2 through binding to Rpn6 to block the assembly of 26S proteasome and the subsequent degradation of ubiquitinated Nrf2. DDO-7263 activates the Nrf2-ARE signaling pathway and exerts anti-inflammatory activity[1].
Related Catalog	Signaling Pathways >> NF-κB >> Keap1-Nrf2 Research Areas >> Inflammation/Immunology
References	[1]. Zhen Dai, et al. Target Fishing Reveals a Novel Mechanism of 1,2,4-Oxadiazole Derivatives Targeting Rpn6, a Subunit of 26S Proteasome. J Med Chem. 2022 Mar 24;65(6):5029-5043.

Molecular Formula	C₁₄H₉F₂N₃O
Molecular Weight	273.24