2484811-36-9

2484811-36-9 structure

2484811-36-9 structure

Name: ATX inhibitor 16
Chemical Name: ATX inhibitor 16
CAS Number: 2484811-36-9
Molecular Formula: C₂₈H₂₇F₃N₆OS₂
Molecular Weight: 584.68
Catalog: Research Areas Cancer
Create Date: 2022-07-08 12:58:45
Modify Date: 2024-01-23 17:16:34
ATX inhibitor 16 is a potent ATX inhibitor with an IC50 of 0.0021 µM. ATX inhibitor 16 shows excellent anti-proliferative activities in breast cancer cells[1].

Name	ATX inhibitor 16

Description	ATX inhibitor 16 is a potent ATX inhibitor with an IC50 of 0.0021 µM. ATX inhibitor 16 shows excellent anti-proliferative activities in breast cancer cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
Target	IC50: 0.0021 µM (ATX)[1]
In Vitro	ATX inhibitor 16 (compound 9j) (0-15 µM; 72 h) shows excellent anti-proliferative activities in breast cancer cells[1]. Cell Cytotoxicity Assay[1] Cell Line: MCF7, MDA-MB-231, A549, H2228 cells Concentration: 0-15 µM Incubation Time: 72 h Result: Exhibited excellent anti-proliferative activities with IC50s of 0.43, 0.31, 10.98, 7.18 µM for MCF7, MDA-MB-231, A549, H2228 cells, respectively.
References	[1]. Lei H,et al. Structure guided design of potent indole-based ATX inhibitors bearing hydrazone moiety with tumor suppression effects. Eur J Med Chem. 2020 Sep 1;201:112456.

Molecular Formula	C₂₈H₂₇F₃N₆OS₂
Molecular Weight	584.68