2484811-36-9

2484811-36-9 structure
2484811-36-9 structure
  • Name: ATX inhibitor 16
  • Chemical Name: ATX inhibitor 16
  • CAS Number: 2484811-36-9
  • Molecular Formula: C28H27F3N6OS2
  • Molecular Weight: 584.68
  • Catalog: Research Areas Cancer
  • Create Date: 2022-07-08 12:58:45
  • Modify Date: 2024-01-23 17:16:34
  • ATX inhibitor 16 is a potent ATX inhibitor with an IC50 of 0.0021 µM. ATX inhibitor 16 shows excellent anti-proliferative activities in breast cancer cells[1].

Name ATX inhibitor 16
Description ATX inhibitor 16 is a potent ATX inhibitor with an IC50 of 0.0021 µM. ATX inhibitor 16 shows excellent anti-proliferative activities in breast cancer cells[1].
Related Catalog
Target

IC50: 0.0021 µM (ATX)[1]

In Vitro ATX inhibitor 16 (compound 9j) (0-15 µM; 72 h) shows excellent anti-proliferative activities in breast cancer cells[1]. Cell Cytotoxicity Assay[1] Cell Line: MCF7, MDA-MB-231, A549, H2228 cells Concentration: 0-15 µM Incubation Time: 72 h Result: Exhibited excellent anti-proliferative activities with IC50s of 0.43, 0.31, 10.98, 7.18 µM for MCF7, MDA-MB-231, A549, H2228 cells, respectively.
References

[1]. Lei H,et al. Structure guided design of potent indole-based ATX inhibitors bearing hydrazone moiety with tumor suppression effects. Eur J Med Chem. 2020 Sep 1;201:112456.

Molecular Formula C28H27F3N6OS2
Molecular Weight 584.68
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