2747915-71-3

2747915-71-3 structure

2747915-71-3 structure

Name: Chlorpheniramine-d4 maleate
Chemical Name: Chlorpheniramine-d4 maleate
CAS Number: 2747915-71-3
Molecular Formula: C₂₀H₁₉D₄ClN₂O₄
Molecular Weight: 394.89
Catalog: Signaling Pathways GPCR/G Protein Histamine Receptor
Create Date: 2022-06-04 15:58:38
Modify Date: 2024-01-03 12:36:45
Chlorpheniramine-d4 (maleate) is deuterium labeled Chlorpheniramine (maleate).

Name	Chlorpheniramine-d4 maleate

Description	Chlorpheniramine-d4 (maleate) is deuterium labeled Chlorpheniramine (maleate).
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Endocrinology Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Histamine Receptor
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Medina, M.A., et al., Chlorpheniramine inhibits the synthesis of ornithine decarboxylase and the proliferation of human breast cancer cell lines. Breast Cancer Res Treat, 1995. 35(2): p. 187-94. [3]. Kelly, J.X., et al., Design, synthesis, and evaluation of 10-N-substituted acridones as novel chemosensitizers in Plasmodium falciparum. Antimicrob Agents Chemother, 2007. 51(11): p. 4133-40. [4]. Iemura, R., et al., Synthesis of 2-(4-substituted-1-piperazinyl)benzimidazoles as H1-antihistaminic agents. J Med Chem, 1986. 29(7): p. 1178-83. [5]. Takano, N., I. Arai, and M. Kurachi, Analysis of the spontaneous scratching behavior by NC/Nga mice: a possible approach to evaluate antipruritics for subjects with atopic dermatitis. Eur J Pharmacol, 2003. 471(3): p. 223-8.

Molecular Formula	C₂₀H₁₉D₄ClN₂O₄
Molecular Weight	394.89