2664932-65-2
2664932-65-2 structure
- Name: Glucocorticoid receptor-IN-2
- Chemical Name: Glucocorticoid receptor-IN-2
- CAS Number: 2664932-65-2
- Molecular Formula: C25H20F4N6O2
- Molecular Weight: 512.46
- Catalog: Signaling Pathways GPCR/G Protein Glucocorticoid Receptor
- Create Date: 2022-06-30 12:23:46
- Modify Date: 2024-01-10 12:02:37
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Glucocorticoid receptor-IN-2 (Compound WX019) is a selective glucocorticoid receptor (GR) modulator with anti-inflammatory effect. Glucocorticoid receptor-IN-2 exhibits very good transcriptional repressive activity with an IC50 of 0.171 nM against hMMP1, and comparable transcriptional activation activity with an EC50 of 0.94 nM against MMTV[1].
| Name | Glucocorticoid receptor-IN-2 |
|---|
| Description | Glucocorticoid receptor-IN-2 (Compound WX019) is a selective glucocorticoid receptor (GR) modulator with anti-inflammatory effect. Glucocorticoid receptor-IN-2 exhibits very good transcriptional repressive activity with an IC50 of 0.171 nM against hMMP1, and comparable transcriptional activation activity with an EC50 of 0.94 nM against MMTV[1]. |
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| Related Catalog | |
| In Vitro | Glucocorticoid receptor-IN-2 (Compound WX019) inhibits human peripheral blood mononuclear cells TNF-α with an IC50 of 0.98 nM[1]. Glucocorticoid receptor-IN-2 shows inhibitory effect on CYP3A4 with an IC50 of 9.12 µM[1]. |
| References |
| Molecular Formula | C25H20F4N6O2 |
|---|---|
| Molecular Weight | 512.46 |