Glucocorticoid receptor-IN-2

Modify Date: 2024-01-10 12:02:37

Glucocorticoid receptor-IN-2 structure	Common Name	Glucocorticoid receptor-IN-2
	CAS Number	2664932-65-2	Molecular Weight	512.46
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₅H₂₀F₄N₆O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Glucocorticoid receptor-IN-2

Glucocorticoid receptor-IN-2 (Compound WX019) is a selective glucocorticoid receptor (GR) modulator with anti-inflammatory effect. Glucocorticoid receptor-IN-2 exhibits very good transcriptional repressive activity with an IC50 of 0.171 nM against hMMP1, and comparable transcriptional activation activity with an EC50 of 0.94 nM against MMTV[1].

Name	Glucocorticoid receptor-IN-2

Description	Glucocorticoid receptor-IN-2 (Compound WX019) is a selective glucocorticoid receptor (GR) modulator with anti-inflammatory effect. Glucocorticoid receptor-IN-2 exhibits very good transcriptional repressive activity with an IC50 of 0.171 nM against hMMP1, and comparable transcriptional activation activity with an EC50 of 0.94 nM against MMTV[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Metabolic Enzyme/Protease >> MMP Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor
In Vitro	Glucocorticoid receptor-IN-2 (Compound WX019) inhibits human peripheral blood mononuclear cells TNF-α with an IC50 of 0.98 nM[1]. Glucocorticoid receptor-IN-2 shows inhibitory effect on CYP3A4 with an IC50 of 9.12 µM[1].
References	[1]. Sheng Su, et al. Benzopyrazole compound. WO2021136429.

Molecular Formula	C₂₅H₂₀F₄N₆O₂
Molecular Weight	512.46

Glucocorticoid receptor-IN-2

Use of Glucocorticoid receptor-IN-2

Names

Glucocorticoid receptor-IN-2 Biological Activity

Chemical & Physical Properties