Name | HIV-1 Integrase inhibitor GS-B |
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Description | HIV-1 Integrase inhibitor GS-B (GS-B) is a novel non-catalytic site integrase inhibitor of HIV-1 integrase (IN), inhibits the interaction between LEDGF IBD and IN with IC50 of 8.1 nM.GS-B displays antiviral potency in MT-4, MT-2, and human PBMCs with EC50 values of 18, 10, and 21 nM, respectively. |
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References | 1. Manuel Tsiang, et al. J Biol Chem. 2012 Jun 15;287(25):21189-203. 2. Mini Balakrishnan, et al. PLoS One. 2013 Sep 9;8(9):e74163. 3. Yoshitsugu Ohata, et al. J Virol. 2022 Jan 19;JVI0184321. |
Molecular Formula | C26H28FNO4 |
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Molecular Weight | 437.511 |