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1470372-00-9

1470372-00-9 structure
1470372-00-9 structure
  • Name: HIV-1 Integrase inhibitor GS-B
  • Chemical Name: HIV-1 Integrase inhibitor GS-B
  • CAS Number: 1470372-00-9
  • Molecular Formula: C26H28FNO4
  • Molecular Weight: 437.511
  • Create Date: 2022-07-02 12:29:33
  • Modify Date: 2024-01-18 21:32:10
  • HIV-1 Integrase inhibitor GS-B (GS-B) is a novel non-catalytic site integrase inhibitor of HIV-1 integrase (IN), inhibits the interaction between LEDGF IBD and IN with IC50 of 8.1 nM.GS-B displays antiviral potency in MT-4, MT-2, and human PBMCs with EC50 values of 18, 10, and 21 nM, respectively.

Name HIV-1 Integrase inhibitor GS-B
Description HIV-1 Integrase inhibitor GS-B (GS-B) is a novel non-catalytic site integrase inhibitor of HIV-1 integrase (IN), inhibits the interaction between LEDGF IBD and IN with IC50 of 8.1 nM.GS-B displays antiviral potency in MT-4, MT-2, and human PBMCs with EC50 values of 18, 10, and 21 nM, respectively.
References 1. Manuel Tsiang, et al. J Biol Chem. 2012 Jun 15;287(25):21189-203. 2. Mini Balakrishnan, et al. PLoS One. 2013 Sep 9;8(9):e74163. 3. Yoshitsugu Ohata, et al. J Virol. 2022 Jan 19;JVI0184321.
Molecular Formula C26H28FNO4
Molecular Weight 437.511