1612927-67-9
1612927-67-9 structure
- Name: SBI-0637142
- Chemical Name: SBI-0637142
- CAS Number: 1612927-67-9
- Molecular Formula: C25H36N4O3S
- Molecular Weight: 472.648
- Create Date: 2022-07-19 15:23:21
- Modify Date: 2025-08-25 11:31:01
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SBI-0637142 is a potent Smac mimetic that preferentially targets BIRC2, latency-reversing agent (LRA), specifically and potently promote HIV-1 latency reversal activity.SBI-0637142 modestly induced HIV-1 latency ex vivo in CD4+ T cells from ART-suppressed aviremic HIV-infected patients as a single agent, showed robust activity when administered in combination with the HDACi panobinostat.SBI-0637142's latency reversal activity is dependent on the NIK-dependent NF-κB signaling.
| Name | SBI-0637142 |
|---|
| Description | SBI-0637142 is a potent Smac mimetic that preferentially targets BIRC2, latency-reversing agent (LRA), specifically and potently promote HIV-1 latency reversal activity.SBI-0637142 modestly induced HIV-1 latency ex vivo in CD4+ T cells from ART-suppressed aviremic HIV-infected patients as a single agent, showed robust activity when administered in combination with the HDACi panobinostat.SBI-0637142's latency reversal activity is dependent on the NIK-dependent NF-κB signaling. |
|---|---|
| References | 1. Pache L, et al. Cell Host Microbe. 2015;18:345-353. 2. Lars Pache, et al. Cell Rep Med. 2020 Jun 23;1(3):100037. |
| Molecular Formula | C25H36N4O3S |
|---|---|
| Molecular Weight | 472.648 |