1612927-67-9

1612927-67-9 structure

Name: SBI-0637142
Chemical Name: SBI-0637142
CAS Number: 1612927-67-9
Molecular Formula: C₂₅H₃₆N₄O₃S
Molecular Weight: 472.648
Create Date: 2022-07-19 15:23:21
Modify Date: 2024-04-06 10:46:05
SBI-0637142 is a potent Smac mimetic that preferentially targets BIRC2, latency-reversing agent (LRA), specifically and potently promote HIV-1 latency reversal activity.SBI-0637142 modestly induced HIV-1 latency ex vivo in CD4+ T cells from ART-suppressed aviremic HIV-infected patients as a single agent, showed robust activity when administered in combination with the HDACi panobinostat.SBI-0637142's latency reversal activity is dependent on the NIK-dependent NF-κB signaling.

Name	SBI-0637142

Description	SBI-0637142 is a potent Smac mimetic that preferentially targets BIRC2, latency-reversing agent (LRA), specifically and potently promote HIV-1 latency reversal activity.SBI-0637142 modestly induced HIV-1 latency ex vivo in CD4+ T cells from ART-suppressed aviremic HIV-infected patients as a single agent, showed robust activity when administered in combination with the HDACi panobinostat.SBI-0637142's latency reversal activity is dependent on the NIK-dependent NF-κB signaling.
References	1. Pache L, et al. Cell Host Microbe. 2015;18:345-353. 2. Lars Pache, et al. Cell Rep Med. 2020 Jun 23;1(3):100037.

Molecular Formula	C₂₅H₃₆N₄O₃S
Molecular Weight	472.648