SBI-0637142
Modify Date: 2024-04-06 10:46:05
SBI-0637142 structure
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Common Name | SBI-0637142 | ||
|---|---|---|---|---|
| CAS Number | 1612927-67-9 | Molecular Weight | 472.648 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H36N4O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SBI-0637142SBI-0637142 is a potent Smac mimetic that preferentially targets BIRC2, latency-reversing agent (LRA), specifically and potently promote HIV-1 latency reversal activity.SBI-0637142 modestly induced HIV-1 latency ex vivo in CD4+ T cells from ART-suppressed aviremic HIV-infected patients as a single agent, showed robust activity when administered in combination with the HDACi panobinostat.SBI-0637142's latency reversal activity is dependent on the NIK-dependent NF-κB signaling. |
| Name | SBI-0637142 |
|---|
| Description | SBI-0637142 is a potent Smac mimetic that preferentially targets BIRC2, latency-reversing agent (LRA), specifically and potently promote HIV-1 latency reversal activity.SBI-0637142 modestly induced HIV-1 latency ex vivo in CD4+ T cells from ART-suppressed aviremic HIV-infected patients as a single agent, showed robust activity when administered in combination with the HDACi panobinostat.SBI-0637142's latency reversal activity is dependent on the NIK-dependent NF-κB signaling. |
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| References | 1. Pache L, et al. Cell Host Microbe. 2015;18:345-353. 2. Lars Pache, et al. Cell Rep Med. 2020 Jun 23;1(3):100037. |
| Molecular Formula | C25H36N4O3S |
|---|---|
| Molecular Weight | 472.648 |