1628793-01-0
1628793-01-0 structure
- Name: FGFR4-IN-2
- Chemical Name: FGFR4-IN-2
- CAS Number: 1628793-01-0
- Molecular Formula: C23H23Cl2N5O5
- Molecular Weight: 520.367
- Create Date: 2022-07-01 13:42:42
- Modify Date: 2024-04-06 11:42:06
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FGFR4-IN-2 is a potent, selective, covalent FGFR4 inhibitor with cellualr IC50 of 8.8 nM, 100-fold selectivity over FGFR2.FGFR4-IN-2 potently and selectively inhibit FGFR4 signaling through covalent modification of Cys552.FGFR4-IN-2 induces tumor regression in preclinical models of orthotopic and sorafenib-resistant HCC.
| Name | FGFR4-IN-2 |
|---|
| Description | FGFR4-IN-2 is a potent, selective, covalent FGFR4 inhibitor with cellualr IC50 of 8.8 nM, 100-fold selectivity over FGFR2.FGFR4-IN-2 potently and selectively inhibit FGFR4 signaling through covalent modification of Cys552.FGFR4-IN-2 induces tumor regression in preclinical models of orthotopic and sorafenib-resistant HCC. |
|---|---|
| References | 1. Haibo Liu, et al. ACS Med Chem Lett. 2020 Mar 6;11(10):1899-1904. |
| Molecular Formula | C23H23Cl2N5O5 |
|---|---|
| Molecular Weight | 520.367 |