FGFR4-IN-2

Modify Date: 2024-04-06 11:42:06

FGFR4-IN-2 Structure
FGFR4-IN-2 structure
 Common Name FGFR4-IN-2
CAS Number 1628793-01-0 Molecular Weight 520.367
Density N/A Boiling Point N/A
Molecular Formula C23H23Cl2N5O5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of FGFR4-IN-2


FGFR4-IN-2 is a potent, selective, covalent FGFR4 inhibitor with cellualr IC50 of 8.8 nM, 100-fold selectivity over FGFR2.FGFR4-IN-2 potently and selectively inhibit FGFR4 signaling through covalent modification of Cys552.FGFR4-IN-2 induces tumor regression in preclinical models of orthotopic and sorafenib-resistant HCC.

 Names

Name FGFR4-IN-2

 FGFR4-IN-2 Biological Activity

Description FGFR4-IN-2 is a potent, selective, covalent FGFR4 inhibitor with cellualr IC50 of 8.8 nM, 100-fold selectivity over FGFR2.FGFR4-IN-2 potently and selectively inhibit FGFR4 signaling through covalent modification of Cys552.FGFR4-IN-2 induces tumor regression in preclinical models of orthotopic and sorafenib-resistant HCC.
References 1. Haibo Liu, et al. ACS Med Chem Lett. 2020 Mar 6;11(10):1899-1904.

 Chemical & Physical Properties

Molecular Formula C23H23Cl2N5O5
Molecular Weight 520.367
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Chemsrc provides FGFR4-IN-2(CAS#:1628793-01-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of FGFR4-IN-2 are included as well.>> amp version: FGFR4-IN-2

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