FGFR4-IN-2
Modify Date: 2025-08-28 19:17:54
FGFR4-IN-2 structure
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Common Name | FGFR4-IN-2 | ||
|---|---|---|---|---|
| CAS Number | 1628793-01-0 | Molecular Weight | 520.367 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H23Cl2N5O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of FGFR4-IN-2FGFR4-IN-2 is a potent, selective, covalent FGFR4 inhibitor with cellualr IC50 of 8.8 nM, 100-fold selectivity over FGFR2.FGFR4-IN-2 potently and selectively inhibit FGFR4 signaling through covalent modification of Cys552.FGFR4-IN-2 induces tumor regression in preclinical models of orthotopic and sorafenib-resistant HCC. |
| Name | FGFR4-IN-2 |
|---|
| Description | FGFR4-IN-2 is a potent, selective, covalent FGFR4 inhibitor with cellualr IC50 of 8.8 nM, 100-fold selectivity over FGFR2.FGFR4-IN-2 potently and selectively inhibit FGFR4 signaling through covalent modification of Cys552.FGFR4-IN-2 induces tumor regression in preclinical models of orthotopic and sorafenib-resistant HCC. |
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| References | 1. Haibo Liu, et al. ACS Med Chem Lett. 2020 Mar 6;11(10):1899-1904. |
| Molecular Formula | C23H23Cl2N5O5 |
|---|---|
| Molecular Weight | 520.367 |
| InChIKey | ZIJVLVUPDVUSMA-UONOGXRCSA-N |
| SMILES | C=CC(=O)NC1COCC1Nc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(C)c2n1 |