2762547-05-5
2762547-05-5 structure
- Name: CD33 splicing modulator 1
- Chemical Name: CD33 splicing modulator 1
- CAS Number: 2762547-05-5
- Molecular Formula: C25H25FN6O
- Molecular Weight: 444.514
- Create Date: 2022-07-01 15:47:24
- Modify Date: 2024-04-09 17:05:41
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CD33 splicing modulator 1 is a small-molecule CD33 pre-mRNA splicing modulator with EC50 of 7.8 uM, enhances the exclusion of CD33 exon 2, reduces full-length V-domain containing CD33 protein.CD33/Siglec 3 is a myeloid lineage cell surface receptor that is known to regulate microglia activity.CD33 splicing modulator 1 reduces full-length V-domain containing CD33 protein in meyloid lineage cells (EC50=2.1 uM), increases exon 2 skipping in cellular mRNA pools.
| Name | CD33 splicing modulator 1 |
|---|
| Description | CD33 splicing modulator 1 is a small-molecule CD33 pre-mRNA splicing modulator with EC50 of 7.8 uM, enhances the exclusion of CD33 exon 2, reduces full-length V-domain containing CD33 protein.CD33/Siglec 3 is a myeloid lineage cell surface receptor that is known to regulate microglia activity.CD33 splicing modulator 1 reduces full-length V-domain containing CD33 protein in meyloid lineage cells (EC50=2.1 uM), increases exon 2 skipping in cellular mRNA pools. |
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| References | 1. Thomas A Chappie, et al. ACS Med Chem Lett. 2022 Jan 4;13(1):55-62. |
| Molecular Formula | C25H25FN6O |
|---|---|
| Molecular Weight | 444.514 |