CD33 splicing modulator 1
Modify Date: 2024-04-09 17:05:41
CD33 splicing modulator 1 structure
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Common Name | CD33 splicing modulator 1 | ||
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| CAS Number | 2762547-05-5 | Molecular Weight | 444.514 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H25FN6O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CD33 splicing modulator 1CD33 splicing modulator 1 is a small-molecule CD33 pre-mRNA splicing modulator with EC50 of 7.8 uM, enhances the exclusion of CD33 exon 2, reduces full-length V-domain containing CD33 protein.CD33/Siglec 3 is a myeloid lineage cell surface receptor that is known to regulate microglia activity.CD33 splicing modulator 1 reduces full-length V-domain containing CD33 protein in meyloid lineage cells (EC50=2.1 uM), increases exon 2 skipping in cellular mRNA pools. |
| Name | CD33 splicing modulator 1 |
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| Description | CD33 splicing modulator 1 is a small-molecule CD33 pre-mRNA splicing modulator with EC50 of 7.8 uM, enhances the exclusion of CD33 exon 2, reduces full-length V-domain containing CD33 protein.CD33/Siglec 3 is a myeloid lineage cell surface receptor that is known to regulate microglia activity.CD33 splicing modulator 1 reduces full-length V-domain containing CD33 protein in meyloid lineage cells (EC50=2.1 uM), increases exon 2 skipping in cellular mRNA pools. |
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| References | 1. Thomas A Chappie, et al. ACS Med Chem Lett. 2022 Jan 4;13(1):55-62. |
| Molecular Formula | C25H25FN6O |
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| Molecular Weight | 444.514 |