2640292-37-9
2640292-37-9 structure
- Name: DDO-6600
- Chemical Name: DDO-6600
- CAS Number: 2640292-37-9
- Molecular Formula: C26H28N4O2
- Molecular Weight: 428.536
- Create Date: 2022-07-01 16:58:47
- Modify Date: 2024-01-07 09:35:14
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DDO-6600 (DDO 6600) is a potent, selective, covalent inhibitor of Hsp90, covalently modifies Cys598 on Hsp90 and disrupts the interaction between Hsp90 and Cdc37 (IC50=6.67 uM).DDO-6600 exhibited antiproliferative activities against multiple tumor cells without inhibiting ATPase activity.DDO-6600 induced the degradation of kinase client proteins in multiple tumor cell lines, promoted apoptosis, and inhibited cell motility.DDO-6600 exhibits antitumor activity in HCT-116 mouse models.
| Name | DDO-6600 |
|---|
| Description | DDO-6600 (DDO 6600) is a potent, selective, covalent inhibitor of Hsp90, covalently modifies Cys598 on Hsp90 and disrupts the interaction between Hsp90 and Cdc37 (IC50=6.67 uM).DDO-6600 exhibited antiproliferative activities against multiple tumor cells without inhibiting ATPase activity.DDO-6600 induced the degradation of kinase client proteins in multiple tumor cell lines, promoted apoptosis, and inhibited cell motility.DDO-6600 exhibits antitumor activity in HCT-116 mouse models. |
|---|---|
| References | 1. Li Li, et al. Cell Chem Biol. 2021 Oct 21;28(10):1446-1459.e6. |
| Molecular Formula | C26H28N4O2 |
|---|---|
| Molecular Weight | 428.536 |