2488762-63-4

2488762-63-4 structure

Name: FGFR-IN-3
Chemical Name: FGFR-IN-3
CAS Number: 2488762-63-4
Molecular Formula: C₁₈H₂₇F₂N₅O₂
Molecular Weight: 383.44
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK FGFR
Create Date: 2022-07-01 11:56:39
Modify Date: 2024-01-09 18:19:10
FGFR-IN-3 (compound 6) is an orally active, potent and BBB-penetrated FGFR (fibroblast growth factor receptor) modulator. FGFR-IN-3 shows neuroprotective activity. FGFR-IN-3 can be used for neurodegenerative diseases research[1].

Name	FGFR-IN-3

Description	FGFR-IN-3 (compound 6) is an orally active, potent and BBB-penetrated FGFR (fibroblast growth factor receptor) modulator. FGFR-IN-3 shows neuroprotective activity. FGFR-IN-3 can be used for neurodegenerative diseases research[1].
Related Catalog	Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FGFR Research Areas >> Neurological Disease
In Vivo	FGFR-IN-3 (compound 6) is sufficiently lipophilic (logP = 2.2) to passively permeate across the blood-brain barrier, and further increase in molecular lipophilicity results in boosting MBI (mechanism-based inactivation) activity[1].
References	[1]. Sakai H, et al. Fibroblast growth factor receptor modulators employing diamines with reduced phospholipidosis-inducing potential. Bioorg Med Chem. 2020 Jul 15;28(14):115562.

Molecular Formula	C₁₈H₂₇F₂N₅O₂
Molecular Weight	383.44