2640217-64-5

2640217-64-5 structure

Name: FGFR-IN-8
Chemical Name: FGFR-IN-8
CAS Number: 2640217-64-5
Molecular Formula: C₂₇H₃₁Cl₂N₉O₂
Molecular Weight: 584.50
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2022-09-16 15:01:26
Modify Date: 2024-04-06 16:31:17
FGFR-IN-8 (Compound 17a) is a highly potent and orally active panFGFR inhibitor against wild-type and mutant FGFRs. FGFR-IN-8 shows inhibition with IC50 values of <0.5, 189.1, <0.5, 22.6, <0.5 and 7.30 nM against FGFR1, V564F-FGFR2, N549H-FGFR2, V555M-FGFR3, FGFR3 and FGFR4, respectively. GFR-IN-8 induces cancer cell apoptosis and shows anticancer activities[1].

Name	FGFR-IN-8

Description	FGFR-IN-8 (Compound 17a) is a highly potent and orally active panFGFR inhibitor against wild-type and mutant FGFRs. FGFR-IN-8 shows inhibition with IC50 values of <0.5, 189.1, <0.5, 22.6, <0.5 and 7.30 nM against FGFR1, V564F-FGFR2, N549H-FGFR2, V555M-FGFR3, FGFR3 and FGFR4, respectively. GFR-IN-8 induces cancer cell apoptosis and shows anticancer activities[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FGFR
Target	FGFR1:<0.5 nM (IC50) V564F-FGFR2:189.1 nM (IC50) N549H-FGFR2:<0.5 nM (IC50) V555M-FGFR3:22.6 nM (IC50) FGFR3:<0.5 nM (IC50) FGFR4:7.30 nM (IC50) V561M-FGFR1:262.5 nM (IC50) K650E-FGFR3:<0.5 nM (IC50) K650M-FGFR3:4.8 nM (IC50)
References	[1]. Ryu S, et al. Identification of Pyridinyltriazine Derivatives as Potent panFGFR Inhibitors against Gatekeeper Mutants for Overcoming Drug Resistance. J Med Chem. 2022 Apr 28;65(8):6017-6038.

Molecular Formula	C₂₇H₃₁Cl₂N₉O₂
Molecular Weight	584.50