2417510-17-7

2417510-17-7 structure

Name: HDAC3/6-IN-2
Chemical Name: HDAC3/6-IN-2
CAS Number: 2417510-17-7
Molecular Formula: C₄₉H₆₇N₅O₆
Molecular Weight: 822.09
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2022-07-11 12:02:13
Modify Date: 2024-01-10 12:56:41
HDAC3/6-IN-2 (compound 15) is a potent HDAC6 and HDAC3 inhibitor, with IC50 values of 0.368 and 0.635 μM, respectively. HDAC3/6-IN-2 shows antitumor activity, and induces cancer cell apoptosis. HDAC3/6-IN-2 decreases the levels of HDAC6 and HDAC3, associated with upregulation of acetylated H3 and α-tubulin[1].

Name	HDAC3/6-IN-2

Description	HDAC3/6-IN-2 (compound 15) is a potent HDAC6 and HDAC3 inhibitor, with IC50 values of 0.368 and 0.635 μM, respectively. HDAC3/6-IN-2 shows antitumor activity, and induces cancer cell apoptosis. HDAC3/6-IN-2 decreases the levels of HDAC6 and HDAC3, associated with upregulation of acetylated H3 and α-tubulin[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> Epigenetics >> HDAC
Target	HDAC6:0.368 μM (IC50) HDAC3:0.635 μM (IC50) HDAC1:2.512 μM (IC50) HDAC2:4.830 μM (IC50)
References	[1]. Huang M, Xie X, Gong P, et al. A 18β-glycyrrhetinic acid conjugate with Vorinostat degrades HDAC3 and HDAC6 with improved antitumor effects. Eur J Med Chem. 2020;188:111991.

Molecular Formula	C₄₉H₆₇N₅O₆
Molecular Weight	822.09