HDAC3/6-IN-2

Modify Date: 2024-01-10 12:56:41

HDAC3/6-IN-2 Structure
HDAC3/6-IN-2 structure
 Common Name HDAC3/6-IN-2
CAS Number 2417510-17-7 Molecular Weight 822.09
Density N/A Boiling Point N/A
Molecular Formula C49H67N5O6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of HDAC3/6-IN-2


HDAC3/6-IN-2 (compound 15) is a potent HDAC6 and HDAC3 inhibitor, with IC50 values of 0.368 and 0.635 μM, respectively. HDAC3/6-IN-2 shows antitumor activity, and induces cancer cell apoptosis. HDAC3/6-IN-2 decreases the levels of HDAC6 and HDAC3, associated with upregulation of acetylated H3 and α-tubulin[1].

 Names

Name HDAC3/6-IN-2

 HDAC3/6-IN-2 Biological Activity

Description HDAC3/6-IN-2 (compound 15) is a potent HDAC6 and HDAC3 inhibitor, with IC50 values of 0.368 and 0.635 μM, respectively. HDAC3/6-IN-2 shows antitumor activity, and induces cancer cell apoptosis. HDAC3/6-IN-2 decreases the levels of HDAC6 and HDAC3, associated with upregulation of acetylated H3 and α-tubulin[1].
Related Catalog
Target

HDAC6:0.368 μM (IC50)

HDAC3:0.635 μM (IC50)

HDAC1:2.512 μM (IC50)

HDAC2:4.830 μM (IC50)

References

[1]. Huang M, Xie X, Gong P, et al. A 18β-glycyrrhetinic acid conjugate with Vorinostat degrades HDAC3 and HDAC6 with improved antitumor effects. Eur J Med Chem. 2020;188:111991.

 Chemical & Physical Properties

Molecular Formula C49H67N5O6
Molecular Weight 822.09
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Chemsrc provides HDAC3/6-IN-2(CAS#:2417510-17-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of HDAC3/6-IN-2 are included as well.>> amp version: HDAC3/6-IN-2

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