Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Palmitic acid
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

2453183-75-8

2453183-75-8 structure

2453183-75-8 structure

Name: Nampt-IN-8
Chemical Name: Nampt-IN-8
CAS Number: 2453183-75-8
Molecular Formula: C₃₆H₃₅N₃O₄
Molecular Weight: 573.68
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2022-06-26 09:49:06
Modify Date: 2025-09-15 18:13:56
Nampt-IN-8 (Compound 10d) is an NAMPT inhibitor with an IC50 of 0.183 μM. Nampt-IN-8 is also a relatively good NQO1 substrate. Nampt-IN-8 induces cell apoptosis and ROS[1].

Name	Nampt-IN-8

Description	Nampt-IN-8 (Compound 10d) is an NAMPT inhibitor with an IC50 of 0.183 μM. Nampt-IN-8 is also a relatively good NQO1 substrate. Nampt-IN-8 induces cell apoptosis and ROS[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ROS Signaling Pathways >> Metabolic Enzyme/Protease >> Nampt
Target	IC50: 0.183 μM (NAMPT)[1]
In Vitro	Nampt-IN-8 (Compound 10d) shows antiproliferative activity with an IC50 of 1.15 μM[1].
In Vivo	Nampt-IN-8 (Compound 10d) (0-20 mg/kg) substantially inhibits the growth of A549/taxol xenograft tumors in vivo with no significant toxicity[1].
References	[1]. Zhang K, et al. Discovery of Small Molecules Simultaneously Targeting NAD(P)H:Quinone Oxidoreductase 1 and Nicotinamide Phosphoribosyltransferase: Treatment of Drug-Resistant Non-small-Cell Lung Cancer. J Med Chem. 2022 Jun 9;65(11):7746-7769.

Molecular Formula	C₃₆H₃₅N₃O₄
Molecular Weight	573.68

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.