2170347-69-8

2170347-69-8 structure

Name: TPB15
Chemical Name: TPB15
CAS Number: 2170347-69-8
Molecular Formula: C₁₈H₉Cl₄N₅O
Molecular Weight: 453.11
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2022-06-30 14:28:04
Modify Date: 2025-08-25 11:08:50
TPB15 is an orally active and potent Hh (Hedgehog) signaling inhibitor. TPB15 markedly induces cell cycle arrest and apoptosis in MDA-MB-468 cells. TPB15 blocks Smo (Smoothened) translocation into the cilia and reduced Smo protein and mRNA expression. TPB15 inhibits the expression of the downstream regulatory factor glioma-associated oncogene 1 (Gli1). TPB15 shows good anti-tumor activity with low toxicity[1].

Name	TPB15

Description	TPB15 is an orally active and potent Hh (Hedgehog) signaling inhibitor. TPB15 markedly induces cell cycle arrest and apoptosis in MDA-MB-468 cells. TPB15 blocks Smo (Smoothened) translocation into the cilia and reduced Smo protein and mRNA expression. TPB15 inhibits the expression of the downstream regulatory factor glioma-associated oncogene 1 (Gli1). TPB15 shows good anti-tumor activity with low toxicity[1].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> Smo Signaling Pathways >> Stem Cell/Wnt >> Gli Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Stem Cell/Wnt >> Hedgehog
References	[1]. Tian N, et al. Discovery of [1,2,4]triazolo[4,3-a]pyridines as potent Smoothened inhibitors targeting the Hedgehog pathway with improved antitumor activity in vivo. Bioorg Med Chem. 2020 Aug 15;28(16):115584.

Molecular Formula	C₁₈H₉Cl₄N₅O
Molecular Weight	453.11