2170347-69-8

2170347-69-8 structure
2170347-69-8 structure
  • Name: TPB15
  • Chemical Name: TPB15
  • CAS Number: 2170347-69-8
  • Molecular Formula: C18H9Cl4N5O
  • Molecular Weight: 453.11
  • Catalog: Signaling Pathways Apoptosis Apoptosis
  • Create Date: 2022-06-30 14:28:04
  • Modify Date: 2024-01-21 09:37:35
  • TPB15 is an orally active and potent Hh (Hedgehog) signaling inhibitor. TPB15 markedly induces cell cycle arrest and apoptosis in MDA-MB-468 cells. TPB15 blocks Smo (Smoothened) translocation into the cilia and reduced Smo protein and mRNA expression. TPB15 inhibits the expression of the downstream regulatory factor glioma-associated oncogene 1 (Gli1). TPB15 shows good anti-tumor activity with low toxicity[1].

Name TPB15
Description TPB15 is an orally active and potent Hh (Hedgehog) signaling inhibitor. TPB15 markedly induces cell cycle arrest and apoptosis in MDA-MB-468 cells. TPB15 blocks Smo (Smoothened) translocation into the cilia and reduced Smo protein and mRNA expression. TPB15 inhibits the expression of the downstream regulatory factor glioma-associated oncogene 1 (Gli1). TPB15 shows good anti-tumor activity with low toxicity[1].
Related Catalog
References

[1]. Tian N, et al. Discovery of [1,2,4]triazolo[4,3-a]pyridines as potent Smoothened inhibitors targeting the Hedgehog pathway with improved antitumor activity in vivo. Bioorg Med Chem. 2020 Aug 15;28(16):115584.

Molecular Formula C18H9Cl4N5O
Molecular Weight 453.11