TPB15
Modify Date: 2025-08-25 11:08:50
TPB15 structure
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Common Name | TPB15 | ||
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| CAS Number | 2170347-69-8 | Molecular Weight | 453.11 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H9Cl4N5O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of TPB15TPB15 is an orally active and potent Hh (Hedgehog) signaling inhibitor. TPB15 markedly induces cell cycle arrest and apoptosis in MDA-MB-468 cells. TPB15 blocks Smo (Smoothened) translocation into the cilia and reduced Smo protein and mRNA expression. TPB15 inhibits the expression of the downstream regulatory factor glioma-associated oncogene 1 (Gli1). TPB15 shows good anti-tumor activity with low toxicity[1]. |
| Name | TPB15 |
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| Description | TPB15 is an orally active and potent Hh (Hedgehog) signaling inhibitor. TPB15 markedly induces cell cycle arrest and apoptosis in MDA-MB-468 cells. TPB15 blocks Smo (Smoothened) translocation into the cilia and reduced Smo protein and mRNA expression. TPB15 inhibits the expression of the downstream regulatory factor glioma-associated oncogene 1 (Gli1). TPB15 shows good anti-tumor activity with low toxicity[1]. |
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| References |
| Molecular Formula | C18H9Cl4N5O |
|---|---|
| Molecular Weight | 453.11 |