2379310-39-9

2379310-39-9 structure

Name: Apoptosis inducer 10
Chemical Name: Apoptosis inducer 10
CAS Number: 2379310-39-9
Molecular Formula: C₂₇H₄₆N₂O₂
Molecular Weight: 430.67
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2022-08-11 21:24:00
Modify Date: 2024-01-10 14:16:01
Apoptosis inducer 10 is a potent apoptosis inducer. Apoptosis inducer 10 shows antiproliferative effect. Apoptosis inducer 10 induces apoptosis in HeLa cancer cells via a mitochondria-dependent endogenous pathway[1].

Name	Apoptosis inducer 10

Description	Apoptosis inducer 10 is a potent apoptosis inducer. Apoptosis inducer 10 shows antiproliferative effect. Apoptosis inducer 10 induces apoptosis in HeLa cancer cells via a mitochondria-dependent endogenous pathway[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
In Vitro	Apoptosis inducer 10 (compound 11) shows cytotoxic activity with IC50s of 7.39, 63.20, 15.28, 15.38, 12.07 µM for HeLa, HL-7702, A549, PC-3, MCF-7 cells, respectively[1]. Apoptosis inducer 10 (2.5, 5, 10 µM) inhibits tumor cell colony formation in A549, HeLa, PC-3 and MCF-7 cells[1]. Apoptosis inducer 10 (2.5, 5, 10 µM; 48 h) induces apoptosis in HeLa cells in a dose dependent manner[1]. Apoptosis inducer 10 (0, 2.5, 5, 10, 20 µM; 72 h) decreases the ratio to the expression of Bcl-2 and Bax in HeLa cells and resultes in the release of cytochrome c, thereby activates caspase-9 and caspase-3, and cleaved PARP proteins[1].
References	[1]. Zhang S, et al. Incorporation of amino moiety to alepterolic acid improve activity against cancer cell lines: Synthesis and biological evaluation. Bioorg Chem. 2020 May;98:103756.

Molecular Formula	C₂₇H₄₆N₂O₂
Molecular Weight	430.67