Apoptosis inducer 10

Modify Date: 2024-01-10 14:16:01

Apoptosis inducer 10 structure	Common Name	Apoptosis inducer 10
	CAS Number	2379310-39-9	Molecular Weight	430.67
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₇H₄₆N₂O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Apoptosis inducer 10

Apoptosis inducer 10 is a potent apoptosis inducer. Apoptosis inducer 10 shows antiproliferative effect. Apoptosis inducer 10 induces apoptosis in HeLa cancer cells via a mitochondria-dependent endogenous pathway[1].

Name	Apoptosis inducer 10

Description	Apoptosis inducer 10 is a potent apoptosis inducer. Apoptosis inducer 10 shows antiproliferative effect. Apoptosis inducer 10 induces apoptosis in HeLa cancer cells via a mitochondria-dependent endogenous pathway[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
In Vitro	Apoptosis inducer 10 (compound 11) shows cytotoxic activity with IC50s of 7.39, 63.20, 15.28, 15.38, 12.07 µM for HeLa, HL-7702, A549, PC-3, MCF-7 cells, respectively[1]. Apoptosis inducer 10 (2.5, 5, 10 µM) inhibits tumor cell colony formation in A549, HeLa, PC-3 and MCF-7 cells[1]. Apoptosis inducer 10 (2.5, 5, 10 µM; 48 h) induces apoptosis in HeLa cells in a dose dependent manner[1]. Apoptosis inducer 10 (0, 2.5, 5, 10, 20 µM; 72 h) decreases the ratio to the expression of Bcl-2 and Bax in HeLa cells and resultes in the release of cytochrome c, thereby activates caspase-9 and caspase-3, and cleaved PARP proteins[1].
References	[1]. Zhang S, et al. Incorporation of amino moiety to alepterolic acid improve activity against cancer cell lines: Synthesis and biological evaluation. Bioorg Chem. 2020 May;98:103756.

Molecular Formula	C₂₇H₄₆N₂O₂
Molecular Weight	430.67