2408286-73-5
2408286-73-5 structure
- Name: HDAC6-IN-10
- Chemical Name: HDAC6-IN-10
- CAS Number: 2408286-73-5
- Molecular Formula: C21H20N4O4
- Molecular Weight: 392.41
- Catalog: Signaling Pathways Cell Cycle/DNA Damage HDAC
- Create Date: 2022-09-19 17:46:30
- Modify Date: 2024-04-09 15:42:42
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HDAC6-IN-10 is a highly selective HDAC6 inhibitor with the IC50 of 0.73 nM. HDAC6-IN-10 has 144~10941-fold selectivity over other HDAC isoforms. HDAC6-IN-10 shows anti-proliferative activities against multiple myeloma cells[1].
| Name | HDAC6-IN-10 |
|---|
| Description | HDAC6-IN-10 is a highly selective HDAC6 inhibitor with the IC50 of 0.73 nM. HDAC6-IN-10 has 144~10941-fold selectivity over other HDAC isoforms. HDAC6-IN-10 shows anti-proliferative activities against multiple myeloma cells[1]. |
|---|---|
| Related Catalog | |
| Target |
HDAC1:8020 nM (IC50) HDAC4:5620 nM (IC50) HDAC5:4370 nM (IC50) HDAC6:0.73 nM (IC50) HDAC7:752 nM (IC50) HDAC8:513 nM (IC50) HDAC9:2560 nM (IC50) HDAC10:105 nM (IC50) HDAC11:1800 nM (IC50) |
| In Vitro | HDAC6-IN-10 (Compound 21b) (0.1-10 μM; 24 h) treatment shows highly selective inhibition against HDAC6[1]. HDAC6-IN-10 (Compound 21b) (0-100 μM; 72 h) treatment shows anti-proliferative activities against two multiple myeloma cells RPMI-8226 and U266[1]. Western Blot Analysis[1] Cell Line: HCT-116 Concentration: 0.1, 1 and 10 μM Incubation Time: 24 hours Result: Showed a dose-dependent increase in the level of Ac-tubulin. Cell Proliferation Assay[1] Cell Line: RPMI-8226 and U266 cells Concentration: 0-100 μM Incubation Time: 72 hours Result: Showed antiproliferative activities against RPMI-8226 and U266 with the IC50s of 33.183 μM and 43.233 μM, respectively. |
| References |
| Molecular Formula | C21H20N4O4 |
|---|---|
| Molecular Weight | 392.41 |