2413603-15-1
2413603-15-1 structure
- Name: HDAC6-IN-5
- Chemical Name: HDAC6-IN-5
- CAS Number: 2413603-15-1
- Molecular Formula: C20H14BrN3O2
- Molecular Weight: 408.25
- Catalog: Signaling Pathways Cell Cycle/DNA Damage HDAC
- Create Date: 2022-07-01 11:59:41
- Modify Date: 2024-01-09 13:10:02
-
HDAC6-IN-5 (compound 11b) is a potent and BBB-penetrated HDAC6 inhibitor, with an IC50 of 0.025 μM. HDAC6-IN-5 exhibits strong inhibitory activity against Aβ1-42 self-aggregation and AChE, with IC50 values of 3.0 and 0.72 μM. HDAC6-IN-5 can enhance neurite outgrowth without significant neurotoxicity[1].
| Name | HDAC6-IN-5 |
|---|
| Description | HDAC6-IN-5 (compound 11b) is a potent and BBB-penetrated HDAC6 inhibitor, with an IC50 of 0.025 μM. HDAC6-IN-5 exhibits strong inhibitory activity against Aβ1-42 self-aggregation and AChE, with IC50 values of 3.0 and 0.72 μM. HDAC6-IN-5 can enhance neurite outgrowth without significant neurotoxicity[1]. |
|---|---|
| Related Catalog | |
| Target |
HDAC6:0.026 ± 0. μM (IC50) HDAC1:0.09 ± 0.0 μM (IC50) HDAC:0.16 ± 0.0 μM (IC50) HDAC3:0.33 ± 0. μM (IC50) HDAC2:0.48 ± 0.0 μM (IC50) HDAC9:5.51 ± 0.0 μM (IC50) HDAC5:7.19 ± 0.4 μM (IC50) HDAC4:7.85 ± 0.6 μM (IC50) HDAC7:9.13 ± 0.3 μM (IC50) |
| In Vitro | HDAC6-IN-5 (compound 11b) induces histone H3 and α-tubulin acetylation in a dose-dependent manner, with EC50 values of 0.58 and 8 μM, respectively[1] |
| References |
| Molecular Formula | C20H14BrN3O2 |
|---|---|
| Molecular Weight | 408.25 |