2446055-29-2
2446055-29-2 structure
- Name: HSP90-IN-13
- Chemical Name: HSP90-IN-13
- CAS Number: 2446055-29-2
- Molecular Formula: C26H21N5O3S
- Molecular Weight: 483.54
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2022-08-21 20:57:36
- Modify Date: 2024-01-11 10:06:53
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HSP90-IN-13 (compound 5k) is a highly potent HSP90 pan inhibitor with an IC50 value of 25.07 nM. HSP90-IN-13 has multi-target activity against EGFR, VEGFR-2 and Topoisomerase-2. HSP90-IN-13 causes cell cycle arrest at G2/M phase and induces apoptosis of MCF-7 cells through mitochondrial-mediated pathway[1].
| Name | HSP90-IN-13 |
|---|
| Description | HSP90-IN-13 (compound 5k) is a highly potent HSP90 pan inhibitor with an IC50 value of 25.07 nM. HSP90-IN-13 has multi-target activity against EGFR, VEGFR-2 and Topoisomerase-2. HSP90-IN-13 causes cell cycle arrest at G2/M phase and induces apoptosis of MCF-7 cells through mitochondrial-mediated pathway[1]. |
|---|---|
| Related Catalog | |
| Target |
HSP90:25.07 nM (IC50) Topoisomerase-2:25.85 nM (IC50) EGFR:38.5 nM (IC50) VEGFR-2:126.95 nM (IC50) |
| In Vitro | HSP90-IN-13 (compound 5k) arrests the cell cycle on MCF-7 at a G2/M phase by 35.06% and induced apoptosis by 19.82%[1]. HSP90-IN-13 has anti-proliferative activity against HCT-116, Hela and MCF-7 cell lines with IC50s of 4.47 μM, 7.55 μM and 4.04 μM, respectively[1]. HSP90-IN-13 has potent multi-target inhibitory activities against EGFR, VEGFR-2 and Topoisomerase-2 with IC50 values of 38.5 nM, 126.95 nM and 25.85 nM, respectively[1]. |
| References |
| Molecular Formula | C26H21N5O3S |
|---|---|
| Molecular Weight | 483.54 |