2446055-29-2

2446055-29-2 structure

Name: HSP90-IN-13
Chemical Name: HSP90-IN-13
CAS Number: 2446055-29-2
Molecular Formula: C₂₆H₂₁N₅O₃S
Molecular Weight: 483.54
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2022-08-21 20:57:36
Modify Date: 2024-01-11 10:06:53
HSP90-IN-13 (compound 5k) is a highly potent HSP90 pan inhibitor with an IC50 value of 25.07 nM. HSP90-IN-13 has multi-target activity against EGFR, VEGFR-2 and Topoisomerase-2. HSP90-IN-13 causes cell cycle arrest at G2/M phase and induces apoptosis of MCF-7 cells through mitochondrial-mediated pathway[1].

Name	HSP90-IN-13

Description	HSP90-IN-13 (compound 5k) is a highly potent HSP90 pan inhibitor with an IC50 value of 25.07 nM. HSP90-IN-13 has multi-target activity against EGFR, VEGFR-2 and Topoisomerase-2. HSP90-IN-13 causes cell cycle arrest at G2/M phase and induces apoptosis of MCF-7 cells through mitochondrial-mediated pathway[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase Signaling Pathways >> Metabolic Enzyme/Protease >> HSP Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR Signaling Pathways >> Cell Cycle/DNA Damage >> HSP Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR
Target	HSP90:25.07 nM (IC50) Topoisomerase-2:25.85 nM (IC50) EGFR:38.5 nM (IC50) VEGFR-2:126.95 nM (IC50)
In Vitro	HSP90-IN-13 (compound 5k) arrests the cell cycle on MCF-7 at a G2/M phase by 35.06% and induced apoptosis by 19.82%[1]. HSP90-IN-13 has anti-proliferative activity against HCT-116, Hela and MCF-7 cell lines with IC50s of 4.47 μM, 7.55 μM and 4.04 μM, respectively[1]. HSP90-IN-13 has potent multi-target inhibitory activities against EGFR, VEGFR-2 and Topoisomerase-2 with IC50 values of 38.5 nM, 126.95 nM and 25.85 nM, respectively[1].
References	[1]. El-Shafey HW, et al. Synthetic approaches, anticancer potential, HSP90 inhibition, multitarget evaluation, molecular modeling and apoptosis mechanistic study of thioquinazolinone skeleton: Promising antibreast cancer agent. Bioorg Chem. 2020 Aug;101:103987.

Molecular Formula	C₂₆H₂₁N₅O₃S
Molecular Weight	483.54

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