2754254-07-2

2754254-07-2 structure

Name: QH536
Chemical Name: QH536
CAS Number: 2754254-07-2
Molecular Formula: C₃₃H₄₉N₃O₃
Molecular Weight: 535.76
Catalog: Signaling Pathways Metabolic Enzyme/Protease HMG-CoA Reductase (HMGCR)
Create Date: 2022-08-16 19:46:12
Modify Date: 2024-01-15 22:43:26
QH536 (Compound 29) is a potent HMGCR degrader with an EC50 of 0.22 μM. QH536 has no side-effect of inducing cholesterol accumulation in cells. QH536 shows anti-inflammatory and can be used for cardiovascular disease and nonalcoholic steatohepatitis research[1].

Name	QH536

Description	QH536 (Compound 29) is a potent HMGCR degrader with an EC50 of 0.22 μM. QH536 has no side-effect of inducing cholesterol accumulation in cells. QH536 shows anti-inflammatory and can be used for cardiovascular disease and nonalcoholic steatohepatitis research[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> HMG-CoA Reductase (HMGCR) Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease
Target	IC50: 0.22 μM (HMGCR)[1]
References	[1]. Li XZ, et al. Synthesis of heterocyclic ring-fused analogs of HMG499 as novel degraders of HMG-CoA reductase that lower cholesterol. Eur J Med Chem. 2022 Jun 5;236:114323.

Molecular Formula	C₃₃H₄₉N₃O₃
Molecular Weight	535.76