2773354-28-0

2773354-28-0 structure

Name: Bcl-2-IN-10
Chemical Name: Bcl-2-IN-10
CAS Number: 2773354-28-0
Molecular Formula: C₂₂H₂₅N₁₁O₁₂
Molecular Weight: 635.50
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2022-09-19 09:21:39
Modify Date: 2024-04-06 12:33:48
Bcl-2-IN-10 is an active Bcl-2 inhibitor that can release up to four nitric oxide (NO) molecules. Bcl-2-IN-10 has cytotoxic activities against cancer cells, such as human leukemia, breast cancer and lung cancer. Bcl-2-IN-10 induces cell apopotosis and arrest cell cycle of G2/M phase, and can be used in cancer-related research[1].

Name	Bcl-2-IN-10

Description	Bcl-2-IN-10 is an active Bcl-2 inhibitor that can release up to four nitric oxide (NO) molecules. Bcl-2-IN-10 has cytotoxic activities against cancer cells, such as human leukemia, breast cancer and lung cancer. Bcl-2-IN-10 induces cell apopotosis and arrest cell cycle of G2/M phase, and can be used in cancer-related research[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Bcl-2 Family Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
Target	Bax
In Vitro	Steroid sulfatase-IN-2 (compound 1, 0-20 μM approximately, 72 h) inhibits different cancer cells with IC50s ranging from 1.26 μM to 17.86 μM[1]. Steroid sulfatase-IN-2 (1 μM, 5 h) releases up to four molecules of nitric oxide[1]. Steroid sulfatase-IN-2 (8 μM, 8-72 h) induces leukemia cell CCRF-CEM apoptosis via MAPKs pathways, arrests cell in the G2/M phase, and increases ratio of Bax/Bcl-2[1]. Apoptosis Analysis[1] Cell Line: CEM cells Concentration: 8 μM Incubation Time: 8, 24, 48 or 72 h Result: Induced apoptosis in a time-dependent and dose-dependent manner. Cell Cycle Analysis[1] Cell Line: CEM cells Concentration: 8 μM Incubation Time: 8, 24, 48 or 72 h Result: Arrested cell in the G2/M phase. Western Blot Analysis[1] Cell Line: CEM cells Concentration: 0-8 μM Incubation Time: 72 h Result: Increased the levels of JNK and p38, and the levels of phosphorylated JNK and p38. Decreased Bcl-2 level in a time- and dose-dependent manner, and increased pro-apoptotic Bax level.
References	[1]. Xun Ji, et al. Double-component diazeniumdiolate derivatives as anti-cancer agents. Bioorg Med Chem. 2020 Apr 15;28(8):115405.

Molecular Formula	C₂₂H₂₅N₁₁O₁₂
Molecular Weight	635.50

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