2232877-85-7
2232877-85-7 structure
- Name: KPC-2-IN-1
- Chemical Name: KPC-2-IN-1
- CAS Number: 2232877-85-7
- Molecular Formula: C13H12BN3O2S
- Molecular Weight: 285.13
- Catalog: Signaling Pathways Anti-infection Bacterial
- Create Date: 2022-09-17 20:01:04
- Modify Date: 2024-01-12 11:22:39
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KPC-2-IN-1, boronic acid derivative, is a potent KPC-2 inhibitor with Ki of 0.032 μM. KPC-2-IN-1 enhances the activity of cefotaxime in KPC-2 expressing E. coli. KPC-2-IN-1 exhibits well tolerated in human HEK-293 cells, which can be used for the study of E. coli resistance to β-lactam antibiotics[1][2].
| Name | KPC-2-IN-1 |
|---|
| Description | KPC-2-IN-1, boronic acid derivative, is a potent KPC-2 inhibitor with Ki of 0.032 μM. KPC-2-IN-1 enhances the activity of cefotaxime in KPC-2 expressing E. coli. KPC-2-IN-1 exhibits well tolerated in human HEK-293 cells, which can be used for the study of E. coli resistance to β-lactam antibiotics[1][2]. |
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| Related Catalog | |
| Target |
Ki: 0.032 μM (KPC-2)[1]. |
| In Vitro | KPC-2-IN-1 (compound 2e) (50 μg/mL; 16 h) enhances the activity of CTX or MEM in KPC-2 expressing E. coli and (5 μg/mL; 16 h) also shows good combination activity of increasing CTX or MEM susceptibility to E. coli NCTC 10418[1]. Cell Viability Assay[1] Cell Line: E. coli BL21 DE3 (KPC-2 producing) and NCTC 10418 Concentration: 5, 50 μg/mL (combine with cefotaxime (CTX) or meropenem (MEM)). Incubation Time: 16 h Result: Decreased the MIC of CTX (16 μg/mL) as well as MEM (>64 μg/mL) to ≤ 0.03 or ≤0.06 μg/mL (~512 to >1000-fold increase in susceptibility) againsted E. coli BL21 DE3 and NCTC 10418. |
| References |
| Molecular Formula | C13H12BN3O2S |
|---|---|
| Molecular Weight | 285.13 |