2785430-89-7
2785430-89-7 structure
- Name: ALK5-IN-33
- Chemical Name: ALK5-IN-33
- CAS Number: 2785430-89-7
- Molecular Formula: C23H23N7O
- Molecular Weight: 413.48
- Catalog: Research Areas Cancer
- Create Date: 2022-10-15 18:59:06
- Modify Date: 2024-04-07 10:06:29
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ALK5-IN-33 (Compound EX-10) is a selective, orally active ALK-5 inhibitor with an IC50 ≤10 nM[1].
| Name | ALK5-IN-33 |
|---|
| Description | ALK5-IN-33 (Compound EX-10) is a selective, orally active ALK-5 inhibitor with an IC50 ≤10 nM[1]. |
|---|---|
| Related Catalog | |
| Target |
ALK5:≤10 nM (IC50) ALK2 |
| In Vitro | ALK-IN-33 (Compound EX-10) shows a high efficiency by inducing a full inhibition (max PIN greater than 75) of TGF-β1 mediated alpha-SMA expression, in at least two donors[1]. |
| In Vivo | ALK-IN-33 (Compound EX-10) (10-100 mg/kg; i.g.; once) reduces the phospho SMAD2 levels in a dose dependent fashion in A549 xenograft model in mice[1]. Animal Model: Female athymic nude mice, A549 xenograft model[1] Dosage: 10, 50, 75 and 100 mg/kg Administration: Oral gavage, once Result: Reduced the phospho SMAD2 levels (p-SMAD2) in a dose dependent fashion. |
| References |
[1]. Bettina FRANZ, et al. Alk-5 inhibitors and uses thereof. Patent WO2022126133A1. |
| Molecular Formula | C23H23N7O |
|---|---|
| Molecular Weight | 413.48 |