2095514-75-1

2095514-75-1 structure

Name: TP-030-1
Chemical Name: TP-030-1
CAS Number: 2095514-75-1
Molecular Formula: C₂₃H₂₂N₄O₃
Molecular Weight: 402.45
Catalog: Signaling Pathways Apoptosis RIP kinase
Create Date: 2022-11-21 16:30:20
Modify Date: 2024-09-16 18:50:21
TP-030-1 is an inhibitor of RIPK1. TP-030-1 inhibits hRIPK1 with a Ki value of 3.9 nM and inhibits mRIPK1 with an IC50 value of 4.2 μM. TP-030-1 can be used for the research of inflammatory diseases and neurodegenerative diseases[1].

Name	TP-030-1

Description	TP-030-1 is an inhibitor of RIPK1. TP-030-1 inhibits hRIPK1 with a Ki value of 3.9 nM and inhibits mRIPK1 with an IC50 value of 4.2 μM. TP-030-1 can be used for the research of inflammatory diseases and neurodegenerative diseases[1].
Related Catalog	Signaling Pathways >> Apoptosis >> RIP kinase Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
In Vitro	TP-030-1 inhibits HT29 necroptosis with an IC50 value of 18 nM[1]. TP-030-1 inhibits hRIPK1 with a Ki value of 3.9 nM[1]. TP-030-1 inhibits mRIPK1 with an IC50 value of 4.2 μM[1].
References	[1]. Msato Yoshikawa, et al. Discovery of 7-Oxo-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridine Derivatives as Potent, Orally Available, and Brain-Penetrating Receptor Interacting Protein 1 (RIP1) Kinase Inhibitors: Analysis of Structure–Kinetic Relationships. J. Med. Chem. 2018, 61, 6, 2384–2409.

Molecular Formula	C₂₃H₂₂N₄O₃
Molecular Weight	402.45