2241676-74-2
2241676-74-2 structure
- Name: 15-PGDH-IN-1
- Chemical Name: 15-PGDH-IN-1
- CAS Number: 2241676-74-2
- Molecular Formula: C24H22N4O2
- Molecular Weight: 398.46
- Catalog: Signaling Pathways Metabolic Enzyme/Protease 15-PGDH
- Create Date: 2022-11-30 11:54:33
- Modify Date: 2024-01-11 08:31:21
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15-PGDH-IN-1 is a potent and orally active 15-PGDH inhibitior. 15-PGDH-IN-1 has inhibition activity against recombinant human 15-PGDH with an IC50 value of 3 nM. 15-PGDH-IN-1 can be used for the research of tissue repair and regeneration[1].
| Name | 15-PGDH-IN-1 |
|---|
| Description | 15-PGDH-IN-1 is a potent and orally active 15-PGDH inhibitior. 15-PGDH-IN-1 has inhibition activity against recombinant human 15-PGDH with an IC50 value of 3 nM. 15-PGDH-IN-1 can be used for the research of tissue repair and regeneration[1]. |
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| Related Catalog | |
| Target |
IC50: 3 nM (15-PGDH)[1] |
| In Vitro | 15-PGDH-IN-1 (compound 49) has inhibition activity against recombinant human 15-PGDH with an IC50 value of 3 nM[1]. 15-PGDH-IN-1 (4, 20, 100, 500, 2500 nM) induces PGE2 in A549 cells at 20 nM[1]. |
| In Vivo | 15-PGDH-IN-1 (compound 49) (5, 10, 20, 40 mg/kg; IV, IP, PO) shows potent inhibition of 15-PGDH, good oral bioavailability, and protective activity in mouse models of ulcerative colitis and recovery from bone marrow transplantation[1]. Animal Model: CD1 Mice (female)[1] Dosage: 5, 10 mg/kg Administration: IV, IP, PO Result: Showed a low Cmax value when dosed orally versus IP, but the AUC was only reduced by half and had good oral bioavailability (63%). Animal Model: C57Bl/6 mice[1] Dosage: 5, 20, 40 mg/kg Administration: IP, Oral Result: Showed elevation of PGE2 levels in colon and lung inhibited 15-PGDH enzymatic activity in the colon. Animal Model: DSS model[1] Dosage: 10, 40 mg/kg Administration: IP (10 mg/kg BID) or PO (40 mg/kg BID) Result: Showed protection in the mouse DSS model of ulcerative colitis. |
| Molecular Formula | C24H22N4O2 |
|---|---|
| Molecular Weight | 398.46 |