1110767-45-7

1110767-45-7 structure

Name: Butyzamide
Chemical Name: Butyzamide
CAS Number: 1110767-45-7
Molecular Formula: C₂₉H₃₂Cl₂N₂O₅S
Molecular Weight: 591.55
Catalog: Signaling Pathways Epigenetics JAK
Create Date: 2023-05-16 09:03:05
Modify Date: 2024-04-05 21:24:16
Butyzamide is an orally active activator of Mpl, a thrombopoietin (TPO) receptor. Butyzamide increases the phosphorylation level of JAK2, STAT3, STAT5 and MAPK. Butyzamide increases the level of human platelets in mouse xenotransplantation assay[1].

Name	Butyzamide

Description	Butyzamide is an orally active activator of Mpl, a thrombopoietin (TPO) receptor. Butyzamide increases the phosphorylation level of JAK2, STAT3, STAT5 and MAPK. Butyzamide increases the level of human platelets in mouse xenotransplantation assay[1].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> STAT Signaling Pathways >> JAK/STAT Signaling >> JAK Signaling Pathways >> Epigenetics >> JAK Signaling Pathways >> Stem Cell/Wnt >> JAK Signaling Pathways >> JAK/STAT Signaling >> STAT Research Areas >> Others Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK
Target	JAK2 STAT3 STAT5
In Vitro	Butyzamide (3 μM；15 分钟) 诱导 Ba/F3-hMpl 细胞中 JAK2、STAT3、STAT5 和 MAPK 的磷酸化[1]。 Butyzamide (3 μM; 48 小时) 诱导人 CD34+ 造血祖细胞产生集落形成单位-巨核细胞和多倍体巨核细胞[1]。
In Vivo	Butyzamide (10 mg/kg、50 mg/kg；口服；每天一次，持续 20 天) 在移植了人胎肝来源的 CD34+ 细胞的 NOG 小鼠内增加人血小板水平[1]。< br/>
References	[1]. Nogami W, et al. The effect of a novel, small non-peptidyl molecule butyzamide on human thrombopoietin receptor and megakaryopoiesis. Haematologica. 2008 Oct;93(10):1495-504.

Molecular Formula	C₂₉H₃₂Cl₂N₂O₅S
Molecular Weight	591.55