Butyzamide
Modify Date: 2024-04-05 21:24:16
Butyzamide structure
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Common Name | Butyzamide | ||
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| CAS Number | 1110767-45-7 | Molecular Weight | 591.55 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C29H32Cl2N2O5S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ButyzamideButyzamide is an orally active activator of Mpl, a thrombopoietin (TPO) receptor. Butyzamide increases the phosphorylation level of JAK2, STAT3, STAT5 and MAPK. Butyzamide increases the level of human platelets in mouse xenotransplantation assay[1]. |
| Name | Butyzamide |
|---|
| Description | Butyzamide is an orally active activator of Mpl, a thrombopoietin (TPO) receptor. Butyzamide increases the phosphorylation level of JAK2, STAT3, STAT5 and MAPK. Butyzamide increases the level of human platelets in mouse xenotransplantation assay[1]. |
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| Related Catalog | |
| Target |
JAK2 STAT3 STAT5 |
| In Vitro | Butyzamide (3 μM；15 分钟) 诱导 Ba/F3-hMpl 细胞中 JAK2、STAT3、STAT5 和 MAPK 的磷酸化[1]。 Butyzamide (3 μM; 48 小时) 诱导人 CD34+ 造血祖细胞产生集落形成单位-巨核细胞和多倍体巨核细胞[1]。 |
| In Vivo | Butyzamide (10 mg/kg、50 mg/kg；口服；每天一次，持续 20 天) 在移植了人胎肝来源的 CD34+ 细胞的 NOG 小鼠内增加人血小板水平[1]。< br/> |
| References |
| Molecular Formula | C29H32Cl2N2O5S |
|---|---|
| Molecular Weight | 591.55 |