α-Hydroxyglutaric acid-13C5 sodium

Modify Date: 2024-01-25 09:21:53

α-Hydroxyglutaric acid-13C5 sodium Structure
α-Hydroxyglutaric acid-13C5 sodium structure
Common Name α-Hydroxyglutaric acid-13C5 sodium
CAS Number 2482467-23-0 Molecular Weight 176.07
Density N/A Boiling Point N/A
Molecular Formula 13C5H8NaO5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of α-Hydroxyglutaric acid-13C5 sodium


α-Hydroxyglutaric acid-13C5 (sodium) is the 13C labeled α-Hydroxyglutaric acid sodium[1]. α-Hydroxyglutaric acid (2-Hydroxyglutarate) sodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid sodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases[2].

 Names

Name α-Hydroxyglutaric acid-13C5 sodium

 α-Hydroxyglutaric acid-13C5 sodium Biological Activity

Description α-Hydroxyglutaric acid-13C5 (sodium) is the 13C labeled α-Hydroxyglutaric acid sodium[1]. α-Hydroxyglutaric acid (2-Hydroxyglutarate) sodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid sodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases[2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Wei Xu, et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell. 2011 Jan 18;19(1):17-30.  

 Chemical & Physical Properties

Molecular Formula 13C5H8NaO5
Molecular Weight 176.07