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2891469-99-9

2891469-99-9 structure

2891469-99-9 structure

Name: JAK-IN-30
Chemical Name: JAK-IN-30
CAS Number: 2891469-99-9
Molecular Formula: C₁₉H₂₆N₈S
Molecular Weight: 398.53
Catalog: Signaling Pathways Epigenetics JAK
Create Date: 2023-09-27 08:09:10
Modify Date: 2024-07-17 11:03:54
JAK-IN-30 (compound 31) is a water-soluble JAK inhibitor with IC50 values of 2, 15, 18 and 2 nM for JAK2, JAK1, JAK3 and TYK2, respectively. JAK-IN-30 has research potential for dry eye disease (DED)[1].

Name	JAK-IN-30

Description	JAK-IN-30 (compound 31) is a water-soluble JAK inhibitor with IC50 values of 2, 15, 18 and 2 nM for JAK2, JAK1, JAK3 and TYK2, respectively. JAK-IN-30 has research potential for dry eye disease (DED)[1].
Related Catalog	Signaling Pathways >> JAK/STAT Signaling >> JAK Signaling Pathways >> Epigenetics >> JAK Signaling Pathways >> Stem Cell/Wnt >> JAK Research Areas >> Inflammation/Immunology
Target	JAK1:15 nM (IC50) JAK2:2 nM (IC50) JAK3:18 nM (IC50) Tyk2:2 nM (IC50)
References	[1]. Gordhan HM, et al. Eyes on Topical Ocular Disposition: The Considered Design of a Lead Janus Kinase (JAK) Inhibitor That Utilizes a Unique Azetidin-3-Amino Bridging Scaffold to Attenuate Off-Target Kinase Activity, While Driving Potency and Aqueous Solubility. J Med Chem. 2023 Jul 13;66(13):8929-8950.

Molecular Formula	C₁₉H₂₆N₈S
Molecular Weight	398.53

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