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Dayang Chem (Hangzhou) Co., Ltd.
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Henan Tianfu Chemical Co., Ltd.
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Zhongshan Xingrui Chemical Co. , Ltd.
China
Product Name: D-(+)-Malic acid
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636-61-3

636-61-3 structure

636-61-3 structure

Name: D-(+)-Malic acid
Chemical Name: (R)-malic acid
CAS Number: 636-61-3
Molecular Formula: C₄H₆O₅
Molecular Weight: 134.087
Catalog: analytical chemistry Standard Food and beverage standards
Create Date: 2018-09-11 16:47:25
Modify Date: 2026-07-03 21:03:47
D-(+)-Malic acid (D-Malic acid), an active enantiomer of Malic acid, is a competitive inhibitor of L(--)malic acid transport[1].

Name	(R)-malic acid
Synonyms	(R)-(+)-2-Hydroxysuccinic acid, D-Hydroxybutanedioic acid (R)-malicaci (R)-(+)-HYDROXYSUCCINIC ACID Malic acid,D D-Afelsaeure D-HYDROXYSUCCINIC ACID (R)-2-Hydroxysuccinic acid (R)-2-Hydroxy-succinic acid (+)-D-MALIC ACID D(+)-Malic D-(+)-Malic acid, 10 mM in DMSO D-(+)-MALIC ACID FOR THE RESOLUTION OF R D-(+)-Malic acid unnatural forM, >= (T) MALIC ACID, D-(+)-(P) (R)-Hydroxybutanedioic acid (R)-2-HYDROXYBUTANEDICBOXYLIC ACID D-(+)-Malic acid,(R)-(+)-2-Hydroxysuccinic acid, D-Hydroxybutanedioic acid Butanedioic acid, hydroxy-, (2R) D-malate hydroxy-,(R)-Butanedioicacid D-(+)-APPLE ACID l(+)-malicaci (R)-HYDROXYSUCCINIC ACID D-Malic Acid abozantinib Impurity D-(+)-MaL L-malic acid (r)-hydroxybutanedioic acid R(+)-2-HYDROXYSUCCINIC ACID Butanedioic acid, 2-hydroxy-, (2R) (2R)-2-Hydroxybutanedioic acid EINECS 211-262-2 dextro-malic acid [R,(+)]-2-Hydroxybutanedioic acid R-Malic acid (R)-2-HYDROXY-SUCCINIC ACID D-APPLE ACID (+)-Malic acid D -Malic acid D-(+)-MALIC ACID (2R)-2-Hydroxysuccinic acid D(+)-Malic acid D-(+)-Malic Acid D-Hydroxybutanedioic acid MFCD00004245 (R)-(+)-MALIC ACID (R)-2-Hydroxysuccinic acid (Cabozantinib Impurity) D-MALIC ACID / (R)-(+)-HYDROXYSUCCINIC ACID D-MALIC ACID D-(+)-2-Hydroxysuccinic acid D-HYDROXYBUTANEDIOIC ACID Butanedioic acid, hydroxy-, (R) (R)-MALIC ACID Malic Acid Impurity 3 (R)-(+)-2-Hydroxysuccinic acid, D-(+)-Malic acid, D-Hydroxybutanedioic acid (2R)-2-hydroxybutanedioate (2R)-2-hydroxybutanedioic acid D-(+)-MalicAcid> 2(R)-hydroxybutanedioic acid D-MALIC ACID 100MG NEAT (2R)-Malic acid MALIC ACID, D-(+)

Description	D-(+)-Malic acid (D-Malic acid), an active enantiomer of Malic acid, is a competitive inhibitor of L(--)malic acid transport[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
In Vitro	Some bacteria belonging to Arthrobacter, Brevibacterium, Corynebacterium, Pseudomonas, Bacillus, and Acinetobacter produced D-(+)-Malic acid (D-Malic acid) from Maleic acid when the cells grown in a medium containing citraconic acid are reacted aerobically with Maleic acid in the pH 7.0 phosphate buffer containing 0.1% sodium chloride[2].
References	[1]. Manuela Côrte-Real, et al. Transport of L(-)malic acid and other dicarboxylic acids in the yeast Candida sphaerica. Appl Microbiol Biotechnol (1989) 31:551-555. [2]. Kiyoshi Nakayama, et al. D-malic acid production from maleic acid using microorganism: Screening of microorganism. Biotechnology Letters volume 15, 271–276(1993).

Density	1.6±0.1 g/cm3
Boiling Point	306.4±27.0 °C at 760 mmHg
Melting Point	98-104ºC
Molecular Formula	C₄H₆O₅
Molecular Weight	134.087
Flash Point	153.4±20.2 °C
Exact Mass	134.021530
PSA	94.83000
LogP	-1.26
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.529

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ON7260000

CHEMICAL NAME :: Malic acid, L(+)-

CAS REGISTRY NUMBER :: 636-61-3

LAST UPDATED :: 199712

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C4-H6-O5

MOLECULAR WEIGHT :: 134.10

WISWESSER LINE NOTATION :: QVYQ1VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 5500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IECHAD Industrial and Engineering Chemistry. (Washington, DC) V.15-62, 1923-70. For publisher information, see CHMTBL. Volume(issue)/page/year: 15,628,1923

Symbol	GHS05, GHS07
Signal Word	Danger
Hazard Statements	H315-H318-H335
Precautionary Statements	P261-P280-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant
Risk Phrases	R36/37/38
Safety Phrases	S26-S37/39
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	ON7260000
HS Code	29181980

Precursor 10
56-84-8 80513-23-1 328-42-7 617-48-1
110-16-7 70-47-3 16045-92-4 87-69-4
1783-96-6 923-06-8
DownStream 9
328-42-7 42890-76-6 38115-87-6 83540-97-0
70681-41-3 7554-28-1 70005-88-8 73991-95-4
59025-03-5

HS Code	2918199090
Summary	2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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