D-(+)-Malic acid

Modify Date: 2024-01-02 15:34:11

D-(+)-Malic acid Structure
D-(+)-Malic acid structure
Common Name D-(+)-Malic acid
CAS Number 636-61-3 Molecular Weight 134.087
Density 1.6±0.1 g/cm3 Boiling Point 306.4±27.0 °C at 760 mmHg
Molecular Formula C4H6O5 Melting Point 98-104ºC
MSDS Chinese USA Flash Point 153.4±20.2 °C
Symbol GHS05 GHS07
GHS05, GHS07
Signal Word Danger

 Use of D-(+)-Malic acid


D-(+)-Malic acid (D-Malic acid), an active enantiomer of Malic acid, is a competitive inhibitor of L(--)malic acid transport[1].

 Names

Name (R)-malic acid
Synonym More Synonyms

 D-(+)-Malic acid Biological Activity

Description D-(+)-Malic acid (D-Malic acid), an active enantiomer of Malic acid, is a competitive inhibitor of L(--)malic acid transport[1].
Related Catalog
In Vitro Some bacteria belonging to Arthrobacter, Brevibacterium, Corynebacterium, Pseudomonas, Bacillus, and Acinetobacter produced D-(+)-Malic acid (D-Malic acid) from Maleic acid when the cells grown in a medium containing citraconic acid are reacted aerobically with Maleic acid in the pH 7.0 phosphate buffer containing 0.1% sodium chloride[2].
References

[1]. Manuela Côrte-Real, et al. Transport of L(-)malic acid and other dicarboxylic acids in the yeast Candida sphaerica. Appl Microbiol Biotechnol (1989) 31:551-555.

[2]. Kiyoshi Nakayama, et al. D-malic acid production from maleic acid using microorganism: Screening of microorganism. Biotechnology Letters volume 15, 271–276(1993).

 Chemical & Physical Properties

Density 1.6±0.1 g/cm3
Boiling Point 306.4±27.0 °C at 760 mmHg
Melting Point 98-104ºC
Molecular Formula C4H6O5
Molecular Weight 134.087
Flash Point 153.4±20.2 °C
Exact Mass 134.021530
PSA 94.83000
LogP -1.26
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.529

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
ON7260000
CHEMICAL NAME :
Malic acid, L(+)-
CAS REGISTRY NUMBER :
636-61-3
LAST UPDATED :
199712
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C4-H6-O5
MOLECULAR WEIGHT :
134.10
WISWESSER LINE NOTATION :
QVYQ1VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
5500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IECHAD Industrial and Engineering Chemistry. (Washington, DC) V.15-62, 1923-70. For publisher information, see CHMTBL. Volume(issue)/page/year: 15,628,1923

 Safety Information

Symbol GHS05 GHS07
GHS05, GHS07
Signal Word Danger
Hazard Statements H315-H318-H335
Precautionary Statements P261-P280-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant
Risk Phrases R36/37/38
Safety Phrases S26-S37/39
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS ON7260000
HS Code 29181980

 Synthetic Route

 Customs

HS Code 2918199090
Summary 2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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 Synonyms

Malic acid, D-
(R)-Hydroxybutanedioic acid
Butanedioic acid, 2-hydroxy-, (2R)-
EINECS 211-262-2
(R)-(+)-HYDROXYSUCCINIC ACID
Malic acid,D
R-Malic acid
D-malate
D-Malic Acid
(R)-2-Hydroxysuccinic acid
(R)-2-Hydroxy-succinic acid
(2R)-2-hydroxybutanedioic acid
2(R)-hydroxybutanedioic acid
(2R)-2-Hydroxysuccinic acid
L-malic acid
(R)-malic acid
D-(+)-Malic Acid
D-Hydroxybutanedioic acid
MFCD00004245
D(+)-Malic acid
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