Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Amino-PEG3-C2-Azido
Price: ￥1650.0/1g ￥5230.0/5g
Purity: 98.0%
Stocking Period: Inquiry
Contact: Liu jia

Chengdu Pukang Biotechnology Co., Ltd.
China
Product Name: Amino-PEG3-C2-Azido
Price: ￥Inquiry/10g
Purity: 95.0%
Stocking Period: Inquiry
Contact: Lihua Yang

DC Chemicals Limited
China
Product Name: Azido-PEG3-amine
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

134179-38-7

134179-38-7 structure

134179-38-7 structure

Name: Amino-PEG3-C2-Azido
Chemical Name: 11-Azido-3,6,9-trioxaundecan-1-amine
CAS Number: 134179-38-7
Molecular Formula: C₈H₁₈N₄O₃
Molecular Weight: 218.25400
Catalog: Chemical reagent Organic reagent Azide
Create Date: 2018-12-28 17:23:13
Modify Date: 2024-01-02 17:27:48
Amino-PEG3-C2-Azido is a PEG-based PROTAC linker can be used in the synthesis of the PARP1 degrader iRucaparib-TP3 (HY-130645)[1].

Name	11-Azido-3,6,9-trioxaundecan-1-amine
Synonyms	Azido-PEG3-Amine Amino-PEG3-Azide 2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethanamine 1-Amino-11-azido-3,6,9-trioxaundecane 11-Amino-3,6,9-trioxaundecanyl Azide

Description	Amino-PEG3-C2-Azido is a PEG-based PROTAC linker can be used in the synthesis of the PARP1 degrader iRucaparib-TP3 (HY-130645)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
In Vitro	Pomalidomide (a CRBN ligand and a known immunomodulatory imide drug (IMiD)) is conjugated to Rucaparib through a tri(ethylene glycol) (PEG3) linker to afford a compound that we designate as iRucaparib-TP3 (IMiD-Rucaparib with a triazole-PEG3 linker). iRucaparib-TP3 induces PARP1 degradation[1].
References	[1]. Wang S, et al. Uncoupling of PARP1 trapping and inhibition using selective PARP1 degradation. Nat Chem Biol. 2019 Dec;15(12):1223-1231.

Density	1.1
Boiling Point	198-202ºC
Molecular Formula	C₈H₁₈N₄O₃
Molecular Weight	218.25400
Exact Mass	218.13800
PSA	103.46000
LogP	0.45826
Index of Refraction	1.47
Storage condition	Amber Vial, Refrigerator, Under Inert Atmosphere

Symbol	GHS05
Signal Word	Danger
Hazard Statements	H314
Precautionary Statements	P280-P305 + P351 + P338-P310
Personal Protective Equipment	Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	C,Xi
Risk Phrases	R34
Safety Phrases	S26-S36/37/39-S45
RIDADR	UN 2735
WGK Germany	3
Packaging Group	III
HS Code	2929909090

Precursor 7
101187-39-7 112-60-7 55400-73-2 86770-67-4
134179-43-4 134179-42-3 65883-12-7
DownStream 3
239081-53-9 875770-34-6 65883-12-7

HS Code	2929909090
Summary	2929909090 other compounds with other nitrogen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%