2568842-26-0

2568842-26-0 structure

Name: JAK2-IN-9
Chemical Name: JAK2-IN-9
CAS Number: 2568842-26-0
Molecular Formula: C₂₀H₂₄N₆O₂S
Molecular Weight: 412.51
Catalog: Signaling Pathways Epigenetics JAK
Create Date: 2023-11-25 17:17:16
Modify Date: 2025-09-10 21:46:56
JAK2-IN-9 (Compound A8) is a selective JAK2 inhibitor (IC50: 5 nM). JAK2-IN-9 inhibits the phosphorylation of JAK2, STAT3, and STAT5. JAK2-IN-9 has metabolic stabilities. JAK2-IN-9 induces apoptosis. JAK2-IN-9 can be used for research of myeloproliferative neoplasms (MPNs)[1].

Name	JAK2-IN-9

Description	JAK2-IN-9 (Compound A8) is a selective JAK2 inhibitor (IC50: 5 nM). JAK2-IN-9 inhibits the phosphorylation of JAK2, STAT3, and STAT5. JAK2-IN-9 has metabolic stabilities. JAK2-IN-9 induces apoptosis. JAK2-IN-9 can be used for research of myeloproliferative neoplasms (MPNs)[1].
Related Catalog	Signaling Pathways >> JAK/STAT Signaling >> JAK Signaling Pathways >> Epigenetics >> JAK Signaling Pathways >> Stem Cell/Wnt >> JAK Research Areas >> Infection Research Areas >> Inflammation/Immunology
Target	JAK2
References	[1]. Tian Y, et al Discovery of N-(4-(Aminomethyl)phenyl)-5-methylpyrimidin-2-amine Derivatives as Potent and Selective JAK2 Inhibitors. ACS Med Chem Lett. 2023 Aug 1;14(8):1113-1121.

Molecular Formula	C₂₀H₂₄N₆O₂S
Molecular Weight	412.51