670267-73-9

670267-73-9 structure

Name: Sirt1/2-IN-2
Chemical Name: Sirt1/2-IN-2
CAS Number: 670267-73-9
Molecular Formula: C₁₈H₁₄N₄O₃S₂
Molecular Weight: 398.46
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2023-10-25 20:58:33
Modify Date: 2025-08-27 16:44:43
Sirt1/2-IN-2 (compound hsa55) is a dual inhibitor of SIRT1/2 with IC50s of 1.8 μM (SIRT1) and 2.4 μM (SIRT2), respsectivley. Sirt1/2-IN-2 completely blocks p53 deacetylation, and increase of p53 and α-tubulin acetylation. Sirt1/2-IN-2 induces apoptosis and shows anti-proliferation activity against human leukemia cell lines[1].

Name	Sirt1/2-IN-2

Description	Sirt1/2-IN-2 (compound hsa55) is a dual inhibitor of SIRT1/2 with IC50s of 1.8 μM (SIRT1) and 2.4 μM (SIRT2), respsectivley. Sirt1/2-IN-2 completely blocks p53 deacetylation, and increase of p53 and α-tubulin acetylation. Sirt1/2-IN-2 induces apoptosis and shows anti-proliferation activity against human leukemia cell lines[1].
Related Catalog	Signaling Pathways >> Epigenetics >> Sirtuin Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Sirtuin
Target	IC50: 1.8 μM (SIRT1), 2.4 μM (SIRT2), 65 μM (SIRT3)[1]
References	[1]. Cai H, et al. Discovery of Novel SIRT1/2 Inhibitors with Effective Cytotoxicity against Human Leukemia Cells. J Chem Inf Model. 2023 Aug 14;63(15):4780-4790.

Molecular Formula	C₁₈H₁₄N₄O₃S₂
Molecular Weight	398.46