Sirt1/2-IN-2

Modify Date: 2024-01-12 14:46:12

Sirt1/2-IN-2 structure	Common Name	Sirt1/2-IN-2
	CAS Number	670267-73-9	Molecular Weight	398.46
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₈H₁₄N₄O₃S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Sirt1/2-IN-2

Sirt1/2-IN-2 (compound hsa55) is a dual inhibitor of SIRT1/2 with IC50s of 1.8 μM (SIRT1) and 2.4 μM (SIRT2), respsectivley. Sirt1/2-IN-2 completely blocks p53 deacetylation, and increase of p53 and α-tubulin acetylation. Sirt1/2-IN-2 induces apoptosis and shows anti-proliferation activity against human leukemia cell lines[1].

Name	Sirt1/2-IN-2

Description	Sirt1/2-IN-2 (compound hsa55) is a dual inhibitor of SIRT1/2 with IC50s of 1.8 μM (SIRT1) and 2.4 μM (SIRT2), respsectivley. Sirt1/2-IN-2 completely blocks p53 deacetylation, and increase of p53 and α-tubulin acetylation. Sirt1/2-IN-2 induces apoptosis and shows anti-proliferation activity against human leukemia cell lines[1].
Related Catalog	Signaling Pathways >> Epigenetics >> Sirtuin Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Sirtuin
Target	IC50: 1.8 μM (SIRT1), 2.4 μM (SIRT2), 65 μM (SIRT3)[1]
References	[1]. Cai H, et al. Discovery of Novel SIRT1/2 Inhibitors with Effective Cytotoxicity against Human Leukemia Cells. J Chem Inf Model. 2023 Aug 14;63(15):4780-4790.

Molecular Formula	C₁₈H₁₄N₄O₃S₂
Molecular Weight	398.46

Sirt1/2-IN-2

Use of Sirt1/2-IN-2

Names

Sirt1/2-IN-2 Biological Activity

Chemical & Physical Properties