2951090-00-7

2951090-00-7 structure

Name: SIRT5 inhibitor 7
Chemical Name: SIRT5 inhibitor 7
CAS Number: 2951090-00-7
Molecular Formula: C₂₈H₃₂ClN₇O₃S
Molecular Weight: 582.12
Catalog: Signaling Pathways Cell Cycle/DNA Damage Sirtuin
Create Date: 2023-11-29 19:05:11
Modify Date: 2024-02-03 18:05:32
SIRT5 inhibitor 7 (compound 58) is a substrate-competitive and selective SIRT5 inhibitor with anti-inflammatory activity. SIRT5 inhibitor 7 has renal protective effects and regulates protein succinylation and the release of pro-inflammatory cytokines. SIRT5 inhibitor 7 has in vivo activity in AKI mouse models of lipopolysaccharide (LPS) and cecal ligation/perforation (CLP)-induced sepsis-related acute kidney injury[1].

Name	SIRT5 inhibitor 7

Description	SIRT5 inhibitor 7 (compound 58) is a substrate-competitive and selective SIRT5 inhibitor with anti-inflammatory activity. SIRT5 inhibitor 7 has renal protective effects and regulates protein succinylation and the release of pro-inflammatory cytokines. SIRT5 inhibitor 7 has in vivo activity in AKI mouse models of lipopolysaccharide (LPS) and cecal ligation/perforation (CLP)-induced sepsis-related acute kidney injury[1].
Related Catalog	Signaling Pathways >> Epigenetics >> Sirtuin Signaling Pathways >> Cell Cycle/DNA Damage >> Sirtuin Research Areas >> Inflammation/Immunology
Target	IC50: 310 nM (SIRT5)[1]
References	[1]. Mou L, et al. Structure-Activity Relationship Studies of 2,4,5-Trisubstituted Pyrimidine Derivatives Leading to the Identification of a Novel and Potent Sirtuin 5 Inhibitor against Sepsis-Associated Acute Kidney Injury. J Med Chem. 2023 Aug 24;66(16):11517-11535..

Molecular Formula	C₂₈H₃₂ClN₇O₃S
Molecular Weight	582.12