474-73-7

474-73-7 structure

Name: 24(S)-Hydroxycholesterol
Chemical Name: (24S)-24-hydroxycholesterol
CAS Number: 474-73-7
Molecular Formula: C₂₇H₄₆O₂
Molecular Weight: 402.653
Catalog: Signaling Pathways Membrane Transporter/Ion Channel iGluR
Create Date: 2018-12-31 17:18:12
Modify Date: 2024-01-05 18:39:40
24(S)-Hydroxycholesterol (24S-OHC), the major brain cholesterol metabolite, plays an important role to maintain homeostasis of cholesterol in the brain. 24(S)-Hydroxycholesterol (24S-OHC) is one of the most efficient endogenous LXR agonist known and is present in the brain and in the circulation at relatively high levels. 24(S)-Hydroxycholesterol (24S-OHC) is a very potent, direct, and selective positive allosteric modulator of NMDARs with a mechanism that does not overlapthat of other allosteric modulators[1][2][3].

Name	(24S)-24-hydroxycholesterol
Synonyms	24S-hydroxycholesterol Cholest-5-ene-3,24-diol cholest-5-en-3beta,24S-diol Cholest-5-ene-3,24-diol, (3β,24S)- cholest-5-ene-3b,24a-diol (3b,24S)-Cholest-5-ene-3,24-diol 24(S)-hydroxycholesterol (3S,8S,9S,10R,13R,14S,17R)-17-[(2R,5S)-5-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol (3β,24S)-Cholest-5-ene-3,24-diol 24S-Cholest-5-ene-3b,24-diol 24S-OHC Cerebrosterol 24-hydroxycholesterol 24S-Hydroxy-cholesterol

Description	24(S)-Hydroxycholesterol (24S-OHC), the major brain cholesterol metabolite, plays an important role to maintain homeostasis of cholesterol in the brain. 24(S)-Hydroxycholesterol (24S-OHC) is one of the most efficient endogenous LXR agonist known and is present in the brain and in the circulation at relatively high levels. 24(S)-Hydroxycholesterol (24S-OHC) is a very potent, direct, and selective positive allosteric modulator of NMDARs with a mechanism that does not overlapthat of other allosteric modulators[1][2][3].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> iGluR Signaling Pathways >> Metabolic Enzyme/Protease >> LXR Research Areas >> Metabolic Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR
Target	Human Endogenous Metabolite
References	[1]. Yuki Kimura, et al. Tocopherol suppresses 24(S)-hydroxycholesterol-induced cell death via inhibition of CaMKII phosphorylation. Biochimie. 2018 Oct;153:203-209. [2]. M Shafaati, et al. Enhanced production of 24S-hydroxycholesterol is not sufficient to drive liver X receptor target genes in vivo. J Intern Med. 2011 Oct;270(4):377-87. [3]. Steven M Paul, et al. The major brain cholesterol metabolite 24(S)-hydroxycholesterol is a potent allosteric modulator of N-methyl-D-aspartate receptors. J Neurosci. 2013 Oct 30;33(44):17290-300.