24(S)-Hydroxycholesterol
Modify Date: 2026-07-11 12:08:58
24(S)-Hydroxycholesterol structure
|
Common Name | 24(S)-Hydroxycholesterol | ||
|---|---|---|---|---|
| CAS Number | 474-73-7 | Molecular Weight | 402.653 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 513.1±23.0 °C at 760 mmHg | |
| Molecular Formula | C27H46O2 | Melting Point | 174-176°C (lit.) | |
| MSDS | N/A | Flash Point | 213.5±17.2 °C | |
Use of 24(S)-Hydroxycholesterol24(S)-Hydroxycholesterol (24S-OHC), the major brain cholesterol metabolite, plays an important role to maintain homeostasis of cholesterol in the brain. 24(S)-Hydroxycholesterol (24S-OHC) is one of the most efficient endogenous LXR agonist known and is present in the brain and in the circulation at relatively high levels. 24(S)-Hydroxycholesterol (24S-OHC) is a very potent, direct, and selective positive allosteric modulator of NMDARs with a mechanism that does not overlapthat of other allosteric modulators[1][2][3]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | (24S)-24-hydroxycholesterol |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | 24(S)-Hydroxycholesterol (24S-OHC), the major brain cholesterol metabolite, plays an important role to maintain homeostasis of cholesterol in the brain. 24(S)-Hydroxycholesterol (24S-OHC) is one of the most efficient endogenous LXR agonist known and is present in the brain and in the circulation at relatively high levels. 24(S)-Hydroxycholesterol (24S-OHC) is a very potent, direct, and selective positive allosteric modulator of NMDARs with a mechanism that does not overlapthat of other allosteric modulators[1][2][3]. |
|---|---|
| Related Catalog | |
| Target |
Human Endogenous Metabolite |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 513.1±23.0 °C at 760 mmHg |
| Melting Point | 174-176°C (lit.) |
| Molecular Formula | C27H46O2 |
| Molecular Weight | 402.653 |
| Flash Point | 213.5±17.2 °C |
| Exact Mass | 402.349792 |
| PSA | 40.46000 |
| LogP | 7.66 |
| Vapour Pressure | 0.0±3.0 mmHg at 25°C |
| Index of Refraction | 1.536 |
| InChIKey | IOWMKBFJCNLRTC-XWXSNNQWSA-N |
| SMILES | CC(C)C(O)CCC(C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C |
| Storage condition | 20°C |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: Increase in light chain 3-GFP+ autophagosome vesicle area per cell in human H4 cells ...
Source: ChEMBL
Target: H4
External Id: CHEMBL937036
|
|
Name: Positive allosteric modulation of recombinant human GluN1/GluN2A receptor stably expr...
Source: ChEMBL
Target: Glutamate receptor ionotropic, NMDA 2A
External Id: CHEMBL4408248
|
|
Name: Positive allosteric modulation of recombinant human GluN1/GluN2A receptor stably expr...
Source: ChEMBL
Target: Glutamate receptor ionotropic, NMDA 2A
External Id: CHEMBL4408249
|
|
Name: Positive allosteric modulation of recombinant human GluN1/GluN2B receptor stably expr...
Source: ChEMBL
Target: Glutamate receptor ionotropic, NMDA 2B
External Id: CHEMBL4408250
|
|
Name: Positive allosteric modulation of recombinant human GluN1/GluN2B receptor stably expr...
Source: ChEMBL
Target: Glutamate receptor ionotropic, NMDA 2B
External Id: CHEMBL4408251
|
|
Name: Concentration required for half maximal activity was calculated in human nuclear oxys...
Source: ChEMBL
Target: Oxysterols receptor LXR-alpha
External Id: CHEMBL710255
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Name: Tested for its ability to activate Liver X receptor-alpha expressed as Relative effic...
Source: ChEMBL
Target: Oxysterols receptor LXR-alpha
External Id: CHEMBL712591
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|
Name: Increase in light chain 3-GFP+ autophagosome vesicle number per cell in human H4 cell...
Source: ChEMBL
Target: H4
External Id: CHEMBL922366
|
|
Name: Human Liver X receptor-alpha (1H. Liver X receptor-like receptors)
Source: IUPHAR-DB
Target: Liver X receptor-alpha (1H. Liver X receptor-like receptors) [Homo sapiens]
External Id: 602_Human
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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| 24S-hydroxycholesterol |
| Cholest-5-ene-3,24-diol |
| cholest-5-en-3beta,24S-diol |
| cholest-5-ene-3b,24a-diol |
| (3b,24S)-Cholest-5-ene-3,24-diol |
| 24(S)-hydroxycholesterol |
| (3S,8S,9S,10R,13R,14S,17R)-17-[(2R,5S)-5-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol |
| (3β,24S)-Cholest-5-ene-3,24-diol |
| 24S-Cholest-5-ene-3b,24-diol |
| 24S-OHC |
| Cerebrosterol |
| 24-hydroxycholesterol |
| 24S-Hydroxy-cholesterol |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the boiling point of (24S)-24-hydroxycholesterol? |
| A: Boiling point of (24S)-24-hydroxycholesterol is 513.1±23.0 °C at 760 mmHg. |
| Q: What is the SMILES notation of (24S)-24-hydroxycholesterol? |
| A: SMILES notation of (24S)-24-hydroxycholesterol is CC(C)C(O)CCC(C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C. |
| Q: What is the InChIKey of (24S)-24-hydroxycholesterol? |
| A: InChIKey of (24S)-24-hydroxycholesterol is IOWMKBFJCNLRTC-XWXSNNQWSA-N. |
| Q: What is the melting point of (24S)-24-hydroxycholesterol? |
| A: Melting point of (24S)-24-hydroxycholesterol is 174-176°C (lit.). |
| Q: What is the Chinese name of 474-73-7? |
| A: Chinese name of 474-73-7 is cholest-5-ene-3β,24(S)-diol. |
| Q: What is the CAS number of (24S)-24-hydroxycholesterol? |
| A: CAS number of (24S)-24-hydroxycholesterol is 474-73-7. |
| Q: What is the molecular weight of (24S)-24-hydroxycholesterol? |
| A: Molecular weight of (24S)-24-hydroxycholesterol is 402.653. |
| Q: What are the storage conditions for (24S)-24-hydroxycholesterol? |
| A: Storage conditions for (24S)-24-hydroxycholesterol: 20°C. |
| Q: What is the English name of (24S)-24-hydroxycholesterol? |
| A: The English name of (24S)-24-hydroxycholesterol is (24S)-24-hydroxycholesterol. |
| Q: What is the LogP of (24S)-24-hydroxycholesterol? |
| A: LogP of (24S)-24-hydroxycholesterol is 7.66. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |